Abstract Introduction Although Hypoactive Sexual Desire Disorder (HSDD) is a common condition with relevant impact on women’s quality of life, approved androgenic formulations for its treatment are lacking. In previous studies, we demonstrated that the administration Dihydrotestosterone (DHT), non-aromatizable androgen, in ovariectomized (OVX) Long-Evans rats primed Estradiol Benzoate (EB), enh...

Abstract Introduction Various agents have been tested to treat female sexual dysfunction (FSD), particularly Hypoactive Sexual Desire Disorder and Female Arousal Disorder, but only two, flibanserin bremelanotide, met any regulatory standards (US only), none is popular with patients or prescribers. Several more agents, e.g., sildenafil, testosterone, alprostadil, buspirone, bupropion trazodone, ...

Abstract Introduction A prevalent concept of neuronal inhibition in sexual response is that it opposes the effects excitation, e.g., classical arm balance which excitation and are on opposite arms balance; when one up, other down (Perelman: Curr Sex Health Rep 2018;10:38). However, there extensive evidence can increase jointly concurrently with excitation. Objective To review increasing various...

BACKGROUND As a mental response to sexual stimuli, sexual desire determines human sexual behavior and represents the cognitive capacity of sexual stimulation, so that avoiding sexual activity has a very negative effect on the discharge of intimacy and joy in couple's relationship and threatens the stability relationship, which can finally end in sexual dissatisfaction and divorce; it may even a...

The Female Sexual Function Index (FSFI) is a brief multidimensional scale for assessing sexual function in women. The scale has received initial psychometric evaluation, including studies of reliability, convergent validity, and discriminant validity (Meston, 2003; Rosen et al., 2000). The present study was designed to crossvalidate the FSFI in several samples of women with mixed sexual dysfunc...

Many underlying psycho-physiological complexities can alter the normal manifestation of sexual responses in women. While these factors may be hormonal changes associated with pregnancy or lactation, medical or surgical debilitating illnesses, relationship issues or socio-cultural and environmental factors, a major hallmark along the life stages is menopause per se. The transition from reproduct...

Metadoxine (pyridoxol L-2-pyrrolidone-5-carboxylate) is an ion-pair salt of pyridoxine (vitamin B6) and 2-pyrrolidone-5-carboxylate (PCA, also known as L-PGA). Metadoxine modulates GABAergic activity, and does not increase levels of brain neurotransmitterssuch as dopamine, norepinephrine and serotonin. In animal studies, Metadoxine has shown no signs of abuse or addiction potential....