BACKGROUND Retrovirus infections among injecting drug users (IDUs), a core at-risk population for both HIV-1 and HTLV-I/II infections in Brazil, were assessed within an ongoing cooperative research. OBJECTIVE The study assessed the seroprevalences of HIV-1 and HTLV-I/II infections, as well as the prevalence of HIV-1 subtypes in a sample of IDUs from Rio de Janeiro, Brazil. An attempt to evalu...

HTLV-I and HTLV-II are endemic in some areas of Brazil, where an associated disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been diagnosed in significant number of infected individuals. Tuberculosis has been demonstrated among those individuals, with higher prevalence than in the general population, suggesting that there is an increased risk for this comorbidit...

We studied a patient with large granular lymphocyte (LGL) leukemia for evidence of human T-cell leukemia/lymphoma virus (HTLV) infection. Serum from this patient was positive for HTLV-I/ II antibodies by enzyme-linked immunosorbent assay (ELISA) and was confirmed positive in Western blot and radioimmunoprecipitation assays. Results of a synthetic peptide-based ELISA showed that the seropositivi...

BACKGROUND Human T-cell lymphotropic virus types Ι and ΙΙ (HTLV-Ι and HTLV-II) are deltaretroviruses which may cause leukemia, lymphoma and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition, HTLV-1 may be related to thalassemia and hemophilia cases after blood transfusion. OBJECTIVES The aim of this study was evaluation of the prevalence of HTLVs in patients with ...

This report is an analysis of results provided to the Centers for Disease Control and Prevention (CDC) by participant laboratories in the Model Performance Evaluation Program (MPEP) after they tested the human T-lymphotropic virus types I and II (HTLV-I/II) performance evaluation samples shipped to them on May 5, 1997. Testing results for this analysis were provided by 185 (86.4%) of 214 labora...

It was observed in the city of Salvador, State of Bahia, the highest seroprevalence of human T cell lymphotropic virus type 1 (HTLV-I) infection in Brazil as demonstrated by national wide blood bank surveys. In this paper, we report results of an investigation of drug use and sexual behavior associated with HTLV-I infection among male and female injecting drug users (IDUs) in Salvador. A cross ...

To determine the susceptibility of rabbits to experimental infection with human T-cell lymphotropic virus type4 (HTLV11). four separate groups of four weanling rabbits each were inoculated intravenously with lethally irradiated HTLV-IIinfected human cell lines Mo-T (HTLV-11,-infected T cells), WIL-NRA (an Epstein-Barr virus [EBVI-transformed B-lymphoblastoid cell line infected with HTLV-I,), 72...

T HE HUMAN lymphotropic virus HTLV-II has been isolated from two patients with a variant T-cell form of hairy cell leukemia (HCL).”2 However, HCL is seen predominantly as a malignancy of B-cell lineage. Some suggestive evidence for HTLV-II in connection with HCL comes from the observation of cell-surface Tac antigen, which is correlated with T cells and selected T-cell malignancies, in B lympho...

Human T cell leukemia virus type I (HTLV-I) is a persistent virus that causes adult T cell leukemia and tropical spastic paraparesis/HTLV-I-associated myelopathy. Studies on rabbits have shown that viral proteins encoded by the open reading frames pX-I and pX-II are required for the establishment of the persistent infection. To examine the in vivo production of these proteins in humans, we have...