نتایج جستجو برای: human calcitonin
تعداد نتایج: 1647951 فیلتر نتایج به سال:
Medullary thyroid cancer is a rare neuroendocrine tumor with aggressive behavior and an uncertain prognosis. Calcitonin the associated marker; however, tumors of lung or intestine can also present high values. We report case 53-year-old patient presenting dry cough for 3 years. Computed tomography (CT) showed 58-mm expansive lesion in right anterior mediastinum cervical ultrasound informed 9-mm...
he observation of ectopic synthesis and secretion polypeptide hormones by nonendo, tumors has been reported with increasing frequency in the past decade. Carcinomas of the lung have been particularly versatile in this regard. Reports have included corticotropin ( adrenocorticotropic hormone) and vasopressin found in some oat-cell carcinomas, gonadotropins predominantly in large-cell carcinomas,...
Calcimimetics are positive allosteric modulators to the calcium-sensing receptor (CaSR). Activation of the CaSR inhibits the secretion of parathyroid hormone (PTH), stimulates the secretion of calcitonin, and decreases serum calcium (Ca(2+)). Cinacalcet, a second-generation calcimimetic, is used therapeutically to control PTH in patients with chronic kidney disease who are on dialysis with seco...
The calcitonin peptides [calcitonin (CT), calcitonin gene-related peptide (CGRP), amylin] share many biological actions, including activity on bone cells. In the present study, CT (10(-11) to 10(-9) M) stimulated [(3)H]thymidine incorporation in primary cultures of human osteoblasts (hOB), as already demonstrated for CGRP and amylin. RT-PCR analysis showed that the calcitonin receptor and the c...
BACKGROUND Glucagon-like peptide-1 receptor agonists, such as dulaglutide, exenatide and liraglutide, are approved to treat Type 2 diabetes mellitus. Although these drugs provide substantial glycaemic control, studies in rodents have prompted concerns about the development of medullary thyroid carcinoma. These data are reflected in the US package insert, with boxed warnings and product labellin...
Tumor cells of a human medullary thyroid carcinoma were isolated and propagated in tissue culture. Several cell lines with different morphology developed from the primary culture, among others a fibroblast-like growing cell line (MTC-F) and a cell line growing as a suspension of single cells and spherical cell clusters (MTC-SK). The MTC-SK cell line was serially propagated for 90 passages, over...
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