Visceral leishmaniasis, or kala-azar, a fatal tropical disease, remains problematic, as early diagnosis is difficult and treatment often results in drug resistance and relapse. We have developed a sensitive enzyme-linked immunosorbent assay (ELISA), using leishmanial membrane antigenic extracts (LAg) to detect specific antibody responses in 25 untreated Indian visceral leishmaniasis patients. T...

Leishmaniasis has been classified primarily as a vector-borne disease that poses a major problem to public health. The Biskra region, which has long been known as a focal point for cutaneous leishmaniasis, has a low extent of visceral leishmaniasis. The aim of the study is to highlight the spatial and temporal evolution of cutaneous and visceral leishmaniasis in Biskra over the last decade, tak...

The levels of protection found in vaccine studies of murine visceral leishmaniasis are significantly lower than for cutaneous leishmaniasis; whether this is due to the high-challenge murine model employed and/or is a consequence of differences required in tissue-specific local immune responses is not understood. Consequently, an intradermal murine model of visceral leishmaniasis has been explor...

BACKGROUND In this paper we study the distribution of leukocyte populations and of cytokine-producing cells in the spleen of a patient with visceral leishmaniasis resistant to clinical treatment. It is the first attempt to compare the distribution of leukocyte populations and cytokine-producing cells in the splenic compartments of a patient with visceral leishmaniasis with those observed in pat...

conclusions: according to our results, it is likely that the increased frequency of the fcγriiib-na1/na2 genotype is associated with impaired immune responses against vl and its subsequent clearance from the patient. results: our results indicated that polymorphisms within the fcγriiib gene (that lead to the expression of the na1/na2 isoforms) are significantly associated with vl. the results d...

Leishmaniasis, a globally prevalent parasitic disease, occurs in three forms, viz, visceral, cutaneous and mucocutaneous. It is transmitted by female Phlebotomus sandflies. Human immunodeficiency virus (HIV) infection is increasing worldwide and several reports indicate a rising trend of VL / HIV co-infection, modifying the traditional anthroponotic pattern of VL transmission. India is one of t...

background: visceral leishmaniasis (vl) is an endemic disease in some parts of iran. many techniques have been used for diagnosis of vl, among which the urine based la-tex agglutination test (katex) is a promising one. objective: to compare three diag-nostic tests of vl including katex, elisa and direct agglutination test (dat) in vl patients and healthy controls in the south west of iran. meth...

leishmania infantum is the most frequent cause of visceral leishmaniasis and l. tropica has been rarely linked to the disease in iran. in this study, bone marrow aspirates were collected from 10 child patients, suspected with visceral leishmaniasis referred to the pediatric wards of kerman medical hospitals, kerman, iran during 2002–2011. leishmania species were identified by using nested pcr i...

The DiseaseLeishmaniasis is vector-borne disease caused by blood and tissue dwelling protozoan parasite species belonging to the genus Leishmania. It is basically a disease of animals that gets into the human population when man, flies and the animal reservoirs coexist in the same environment. In man, infections with Leishmania parasites results in a broad range of clinical manifestations invol...

A vaccine against different forms of leishmaniasis should be feasible considering the wealth of information on genetics and biology of the parasite, clinical and experimental immunology of leishmaniasis, and the availability of vaccines that can protect experimental animals against challenge with different Leishmania species. However, there is no vaccine against any form of leishmaniasis for ge...