نتایج جستجو برای: humanization

تعداد نتایج: 906  

Journal: :The Journal of biological chemistry 2008
Koki Makabe Takeshi Nakanishi Kouhei Tsumoto Yoshikazu Tanaka Hidemasa Kondo Mitsuo Umetsu Yukiko Sone Ryutaro Asano Izumi Kumagai

To investigate the role of Vernier zone residues, which are comprised in the framework regions and underlie the complementarity-determining regions (CDRs) of antibodies, in the specific, high affinity interactions of antibodies with their targets, we focused on the variable domain fragment of murine anti-human epidermal growth factor receptor antibody 528 (m528Fv). Grafting of the CDRs of m528F...

2018
Loukia G. Karacosta John C. Fisk Joseph Jessee Swetha Tati Bradley Turner Diala Ghazal Rachel Ludwig Holly Johnson Julia Adams Munawwar Sajjad Steven Koury Rene Roy James R. Olson Kate Rittenhouse-Olson

The tumor specificity of JAA-F11, a novel monoclonal antibody specific for the Thomsen-Friedenreich cancer antigen (TF-Ag-alpha linked), has been comprehensively studied by in vitro immunohistochemical (IHC) staining of human tumor and normal tissue microarrays and in vivo biodistribution and imaging by micro-positron emission tomography imaging in breast and lung tumor models in mice. The IHC ...

Journal: :Japanese Journal of Thrombosis and Hemostasis 1993

Journal: :DEStech Transactions on Social Science, Education and Human Science 2020

Journal: :Millenium - Journal of Education, Technologies, and Health 2017

Journal: :Interdyscyplinarne Konteksty Pedagogiki Specjalnej 2018

Journal: :Journal of Ethnic and Cultural Studies 2014

Journal: :Revista Brasileira de Enfermagem 2020

Journal: :Business & Information Systems Engineering 2022

Abstract Decision support systems are increasingly being adopted by various digital platforms. However, prior research has shown that certain contexts can induce algorithm aversion, leading people to reject their decision support. This paper investigates how and why the context in which users making decisions (for-profit versus prosocial microlending decisions) affects degree of aversion ultima...

Journal: :International Journal of Advanced Engineering Research and Science 2022

The public disservice in health has become part of the daily lives citizens, even with policies humanization and decentralization services, representing an exceptional milestone for Brazilian health. Thus, this research will investigate proposal services to users, line article 6 Federal Constitution Brazil (1988), Universal Declaration Human Rights. It consists a bibliographic survey, which it ...

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