Spinal stimulation for neuropathic treatment was modeled by incorporating and inhibitory junctions and a volume conductor into Hodgkin-Huxley and Frankenhaeuser-Huxley axon models. Results indicate successful merging of the models at low resistivity values but also show that these two mechanisms operate independently of one another. At high resistivity values, the model no longer produces relia...

The Hodgkin–Huxley model was developed to characterize the action potential of a squid axon. It has served as an archetype for compartmental models of the electrophysiology of biological membranes. Thus the dynamics of the Hodgkin–Huxley model have been extensively studied both with a view to their biological implications and as a test bed for numerical methods that can be applied to more compl...

A recent paper of B. Naundorf et al. described an intriguing negative correlation between variability of the onset potential at which an action potential occurs (the onset span) and the rapidity of action potential initiation (the onset rapidity). This correlation was demonstrated in numerical simulations of the Hodgkin-Huxley model. Due to this antagonism, it is argued that Hodgkin-Huxley-type...

The contraction of a muscle generates a force that decreases when increasing the contraction velocity. This "hyperbolic" force-velocity relationship has been known since the seminal work of A. V. Hill in 1938 [Hill AV (1938) Proc R Soc Lond B Biol Sci 126(843):136-195]. Hill's heuristic equation is still used, and the sliding-filament theory for the sarcomere [Huxley H, Hanson J (1954) Nature 1...

Darwin never wrote much about the brain, but Darwin’s nemesis, Richard Owen, tried in 1861 to protect humans from Darwin’s threatening ideas by arguing that human brains differ fundamentally from those of other apes. This argument provoked a spirited attack by Darwin’s “bulldog,” T. H. Huxley. Darwin did not comment publicly on this controversy, but for the second edition of his Descent of Man,...

Reseña de Lone Heroes and the Myth of American West in Comic Books, 1945-1962 David Huxley (Palgrave MacMillan) y The Book Westerns. New Perspectives on a Global Genre (Christopher Conway Antoinette Sol, editors) University Nebraska Press.

In this work, we consider the forced generalized Burgers-Huxley equation and establish existence uniqueness of a global weak solution using Faedo-Galerkin approximation method. Under smoothness assumptions on initial data external forcing, also obtain further regularity results solutions. Taking forcing to be zero, positivity result as well bound classical are estab...