In polymerase chain reaction (PCR) product analysis, a comparison of target amplicon yield to such PCR artifacts as primer-dimers and misprimed secondary products is essential in PCR assay optimization. This process requires accurate and reproducible measurement of amplified DNA products over a wide range of sizes and concentrations. The 2100 Bioanalyzer is ideally suited to provide rapid quant...

Globally, deaths from aortic aneurysm have increased over the past three decades. Primary drivers of these changes time and whether preventative efforts led to a reduction in remains unknown. We sought characterize impact demographics risk factors on using global database. queried Global Burden Disease Study for number 1990 2019 as well percentage attributable each factor identified by modeling...

This paper explores the decay of linkage disequilibrium (LD) on the autosomes and chromosome X. The extent of marker-marker LD is important for both linkage and association studies. The analysis of the Caucasian sample from the Collaborative Study on the Genetics of Alcoholism study revealed the expected negative relationship between the magnitude of the marker-marker LD and distance (cM), with...

Rigidity matrices for multi-layered media are derived for isotropic and orthotropic layers by a simple direct procedure which brings to light their fundamental mathematical structure. The method was introduced many years ago by the author in the more general context of dynamics and stability of multi-layers under initial stress. Other earlier results are also briefly recalled such as the deriva...

There are likely to be significant demographic and economic pressures on health care systems in Europe over the coming years. The elderly population is set to increase, both in numbers and in proportion to the working age population. This represents a doubling in the ratio of elderly people to those of current working ages. This will create substantial new costs – of health and social care and ...

an in nite-state system into a nite-state one. This suggests an alternative approach to the temporal veri cation of in nite-state systems: abstract rst and model check later. In this work, we present a general framework for abstracting an arbitrary (in nite-state) reactive system D and its speci cation expressed as a linear temporal logic (ltl) formula , to a nite state problem that can be mode...

This paper makes two generalisations of categorial calculus of discontinuity. In the rst we introduce unary modalities which mediate between continuous and discontinuous strings. In the second each of the modes of adjunction of the proposal to date, concatenation, juxtaposition and interpolation, are augmented with variants. Linguistic illustration and motivation is provided, and we show how ad...

This thesis investigates the synthesis of controllers for time varying systems in order to satisfy an induced 2-norm closed loop performance bound. This performance criterion is a generalisation of the well known H1 norm criterion used in the frequency domain for analysis and synthesis of linear time invariant control systems. A number of di erent time varying system frameworks are considered, ...