Introduction: Oral lichen planus (OLP) is an autoimmune disease with uncertain etiopathogenecity and no definitive treatment. Considering the recurrent nature of OLP, finding an adjunctive treatment to minimize the risk of chronicity and recurrence of OLP and to decrease the adverse effects of corticosteroids can be promising. This study aimed to assess the efficacy of a mixture of hyaluronic a...

Background Hyaluronan is a critical component of the extracellular matrix and contributes significantly to tissue hydrodynamics and cell migration and proliferation. Studies have demonstrated its anti-inflammatory, antibacterial, and regenerative effects. The present study aimed to assess the clinical effects of the subgingival application of 0.8% hyaluronic acid gel as an adjunct to scaling an...

Streptococcus pneumoniae hyaluronate lyase (spnHL) is a pathogenic bacterial spreading factor and cleaves hyaluronan, an important constituent of the extra- cellular matrix of connective tissues, through an enzymatic beta-elimination process, different from the hyaluronan degradation by hydrolases in animals. The mechanism of hyaluronan binding and degradation was proposed based on the 1.56 A r...

Skin aging is a biological process leading to visible skin alterations. The mechanism of action, clinical efficacy and tolerance novel anti-wrinkle technology were evaluated in two care products formulated for different types. Two single-arm monocentric, open-label observational studies, which 56 days long, cream-gel (n = 30) cream 33) on the face neck. Morphometric analyses five types wrinkles...

New hyaluronic acid-itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers. Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investiga...

Perineuronal nets (PNNs) are presumed to limit plasticity in adult animals. Ischaemic stroke results the massive breakdown of PNNs resulting rejuvenating states neuronal plasticity, but mechanisms this phenomenon largely unknown. As hyaluronic acid (HA) is structural backbone PNNs, we hypothesized that these changes a consequence altered expression HA metabolism enzymes. Additionally, investiga...

An unripe apple (immature fruit of Malus pumila Mill) contains more polyphenols than mature fruit. To explore the anti-photoaging effects extract (UAE), we investigated UAE on wrinkle improvement, skin moisturizing, inflammation, and antioxidant activities using ultraviolet B (UVB)-irradiated SKH1-hr hairless mouse model. The mice were irradiated with UVB (0.18 J/cm2) three times per week orall...