PURPOSE To evaluate the efficacy of subconjunctival bevacizumab (ScB) as adjuvant therapy to primary trabeculectomy with mitomycin C (MMC) in primary open-angle glaucoma. MATERIALS AND METHODS Forty-six eyes of primary open-angle glaucoma patients were randomized to receive ScB (1.25 mg/0.05 mL) injections (the MMC+ScB group) at the end of the operations, or sham-treated controls (the MMC gro...

Objective Sodium bicarbonate has been reported to maximize the efficacy of intravesical instillation of mitomycin-C (IVI-MMC) therapy by urine alkalinization in non-muscle-invasive bladder cancer (NMIBC). This study aimed to analyze the changes in MMC concentration according to urinary pH and evaluate the efficacy of sodium bicarbonate to maintain the concentration of active form of MMC during ...

Due to the scalability and flexibility in power transmission, the Modular Multilevel Converter (MMC) receives a widespread favor since its advent. The popularization of the MMC will continuously promote the developments in renewable energy grid connecting and flexible High Voltage Direct Current transmission (HVDC) system. In this paper, an overview of the most recent effort associated with the...

The serial hybrid line commutated converter-modular multilevel converter (LCC-MMC) high voltage direct current (HVDC) system has structural features that cause the inverter side three MMCs to form a closed-loop after DC fault. If steady-state control strategy of is still used during phase shift, there will be severe overcurrent problem. In addition, power recovery process, rectifier and main MM...

The coexistence of myelomeningocele (MMC) and split cord malformation (SCM) is a well-known phenomenon. The SCM is usually above or at the level of the MMC. Split cord malformation distal to the MMC is considered to be the rarest form of such a combination. We report a case of SCM (type I) distal to the MMC diagnosed pre-operatively. Repair of the MMC and the SCM were carried out in the same se...

Since 1984, mitomycin C (MMC) has been applied in the treatment of non-small-cell lung cancer (NSCLC). MMC-based chemotherapeutic regimens are still under consideration owing to the efficacy and low cost as compared with other second-line regimens in patients with advanced NSCLC. Hence, it is important to investigate whether MMC induces potential negative effects in NSCLC. Here, we found that t...

Multiple myeloma is characterized by the clonal expansion of malignant plasma cells (multiple myeloma cells [MMCs]), in the bone marrow. Osteolytic bone lesions are detected in 80% of patients because of increased osteoclastic bone resorption and reduced osteoblastic bone formation. MMCs are found closely associated with sites of increased bone resorption. Osteoclasts strongly support MMC survi...

Reducing the capacitor voltage ripples of half-bridge submodules (HBSM) and full-bridge (FBSM) in a hybrid modular multilevel converter (MMC) is expected to reduce capacitance, volume, costs. To address this issue, article proposes dual harmonic injection method which injects second circulating current third-order into conventional MMC control. First, mathematical model proposed control establi...

The classical utilized double emulsion solvent diffusion technique for encapsulating water soluble Mitomycin C (MMC) in PLA nanoparticles suffers from low encapsulation efficiency because of the drug rapid partitioning to the external aqueous phase. In this paper, MMC loaded PLA nanoparticles were prepared by a new single emulsion solvent evaporation method, in which soybean phosphatidylcholine...