OBJECTIVE To compare the effects of sodium depletion and of angiotensin I converting enzyme inhibition on microalbuminuria in insulin dependent diabetes. DESIGN Randomised, double blind, double dummy parallel study of normotensive diabetic patients with persistent microalbuminuria (30-300 mg/24 h) treated with enalapril or hydrochlorothiazide for one year after a three month, single blind pla...

Hydrochlorothiazide, an antihypertensive and diuretic drug only for clinic purpose, was recently found as adulterant in functional foods. Due to the potential health risk, it is urgent develop a simple rapid assay its identification. In this work, two hapten structures were rationally designed based on molecular modeling, highly sensitive antibody hydrochlorothiazide obtained with 50% inhibitiv...

Losartan potassium, Valsartan , Telmisartan and Irbesartan are angiotensin-II-receptor antagonists (ARA II) group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists (ARA-IIs) in presence of Hydrochlorothiazide. The method was performed by reversed ph...

OBJECTIVES The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension. METHODS Outpatients (N = 793) 18-70 years of age with stage 2 or severe hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg) were recruited from four randomly selec...

Losartan potassium, Valsartan , Telmisartan and Irbesartan are angiotensin-II-receptor antagonists (ARA II) group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists (ARA-IIs) in presence of Hydrochlorothiazide. The method was performed by reversed ph...

BACKGROUND Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. OBJECTIVE To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. DESIGN Propensity score-matched observational cohort study with up to 5 years of follow-up. SETTING Ontario, Canada. PATIENTS All individuals aged 66 ye...

Introduction. Combined drugs have the greatest efficacy and safety in arterial hypertension treatment. The combination of candesartan hydrochlorothiazide (AT1-receptor antagonist a thiazide diuretic, respectively) provides high efficiency antihypertensive therapy, therefore it is widely used medical practice. Developing method for simultaneous determination hydrochlorithiazide human blood plasm...

The present study explored the modulatory potential of hydrochlorothiazide and triamterene on resistant hypertension patients. The mechanistic information for resistant hypertension was explored by studying the pressure-natriuresis curves between the salt sensitive population and non-salt sensitive population. A cohort of 23 patients with non-hypertension (NH) (13 males and 10 females; aged fro...