Product design in the early stages requires a more quantitative process to ensure that simulation study's outcome will meet expectations. The purpose of this study was determine whether manufacturing software package could effectively evaluate and validate conceptualised blank tooling manufacture sizeable complex- shaped aluminium alloy aircraft panel using die sheet hydroforming. Blank tool co...

We report on the results of a comparative study in which the mechanical response of both fully dense and porous lowdielectric thin films was evaluated using two different techniques: nanoindentation and the plane-strain bulge test. Stiffness values measured by nanoindentation are systematically higher than those obtained using the bulge test technique. The difference between the measurements is...

In sheet metal forming, very often, large plastic deformations are imposed to a thin plate. An accurate description of the material’s elastoplastic response is therefore paramount importance perform finite element (FE) simulations an actual forming operation. Reliable stressstrain data till significantly larger strains compared tensile tests can be identified by means bulge test. this work, dyn...

HIV-1 replication requires binding to occur between Trans-activation Response Element (TAR) RNA and the TAT protein. This TAR-TAT binding depends on the conformation of TAR, and therapeutic development has attempted to exploit this dynamic behavior. Here we simulate TAR dynamics in the context of mutations inhibiting TAR binding. We find that two tertiary elements, the apical loop and the bulge...