Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This may be caused by altered metabolism by nonsynonymous single-nucleotide polymorphisms (ns-SNPs) in genes encoding aldo-keto reductases (AKRs) and carbonyl reductases. This study examined the effect of 27 ns-SNPs, in eight human genes, on ...

The very large expansion upon adsorption of liquids, up to 160% in cell volume, has been observed in the iron(iii) trans,trans muconate MIL-89 [(MIL = Material Institut Lavoisier]. The structure of lutidine-containing MIL-89 (lutidine = 2,6-dimethylpyridine) has been determined using X-ray powder diffraction and computer simulations. Finally, the consequences of adsorption of various polar and ...

1. Sureau P, Rousilhon JP, Capponi M. Le typhus murin à Dalat: état actuel de la question. Isolement d’une souche. Bull Soc Pathol Exot. Fileales. 1955;48:599–602. PMID 13329703 2. Beytout D. Rickettsioses diagnostiquées par microagglutination de Janvier 1962 a Juin 1963 a Saigon. Bull Soc Pathol Exot Filiales. 1964;57:257–63. 3. Deaton JG. Febrile illnesses in the tropics (Vietnam). Mil Med. 1...

The adsorption of methyl iodide is studled on Mo (100) where ultraviolet photoelectron spectroscopy shows that the methyl lo&de thermally decomposes to form methyl species on warming to ~200 K This self-hydrogenates to yMd methane which desorbs at ~230 K and predosmg the surface with deuterium forms essentially only CH3D lndxcatmg that the methyl species reacts with adsorbed hydrogen and that t...

Ab initio molecular dynamics and quantum chemistry techniques are used to calculate the structure, vibrational frequencies, and carbon-isotope fractionation factors of the carbon dioxide component [CO(2)(m)] of soil (oxy)hydroxide minerals goethite, diaspore, and gibbsite. We have identified two possible pathways of incorporation of CO(2)(m) into (oxy)hydroxide crystal structures: one in which ...

mil-53-cu has been synthesized hydrothermally and has been used for the first time for gas separation. mil-53-cu shows adsorption capacities of 8.1, 0.7 and 0.5 m.mol/g, respectively, for ch4, co2 and h2 at 30 bar and 298 k. the high ch4 adsorption capacity of mil-53-cu maybe attributed to the high pore volume and large number of open metal sites. the high selectivity for ch4 over co2 (11.5) an...

Abstract Two-dimensional (2D) transition metal carbonitrides (MXene) have attracted growing interest in electrocatalytic hydrogen production due to its structural and electronic properties. In this work, the evolution reaction (HER) activity of all 64 O-terminated ordered double form M? 2 M?CNO (M? = Ti, V, Cr, Zr, Nb, Mo, Hf, Ta; M? Ta) has been investigated by well-defined density functional ...