In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectrosco...

A micromechanical model was developed to predict the elastic moduli of hydroxyapatite (HA) whisker reinforced polymer biocomposites based upon the elastic properties of each phase and the reinforcement volume fraction, morphology, and preferred orientation. The effects of the HA whisker volume fraction, morphology, and orientation distribution were investigated by comparing model predictions wi...

A novel approach for depositing hydroxyapatite (HA) films on titanium substrates by using mechanical alloying (MA) technique has been developed. However, it was shown that one-hour heat treatment at 800°C of such mechanically coated HA layer leads to partial transformation of desired HA phase to beta-tri-calcium phosphate (β-TCP) phase. It appears that the grain boundary and interface defects f...

Hydroxyapatite (HA) scaffolds with a 3-D periodic architecture and multiscale porosity have been fabricated by direct-write assembly. Concentrated HA inks with tailored viscoelastic properties were developed to enable the construction of complex 3-D architectures comprised of self-supporting cylindrical rods in a layer-by-layer patterning sequence. By controlling their lattice constant and sint...

The use of porous blocks is limited, however, because hydroxyapatite has only modest tensile strength and a low fracture toughness, leaving it susceptible to fracture or fragmentation if subjected to mechanical loading. Incorporating hydroxyapatite granules into a biocompatible polymeric matrix produces a more robust material. Judicious selection of the loading level of the HA allows for a high...

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Hydroxyapatite (HA) is one of the most common biocompatible ceramic with wide usages in various aspects of medicine due to the resemblance to the mineral bone tissue. The particle size of HA has a key roll in determination of the reaction rate at the interface of natural bones/artificial. Accordingly, this paper tries to propose a novel approach for the preparation of HA nanoparticles from natu...

BACKGROUND AND PURPOSE Hydroxyapatite (HA) coating stimulates the osseointegration of cementless orthopedic implants. Recently, locally released osteogenic growth factors have also been shown experimentally to stimulate osseointegration so that bone fills gaps around orthopedic implants. Here, we have compared the effect of local release of TGF-beta1 and IGF-1 with that of hydroxyapatite coatin...

Several studies were carried out in order to reduce the systemic use of antibiotics due to the high concentration required to provide the minimum inhibitory concentration (MIC) at infected sites. The aim of this study was to develop a system of drug adsorption onto commercial hydroxyapatite (HA, Ca10(PO4)6(OH)2) and glass reinforced hydroxyapatite (GR-HA) granules. The drug will then be release...

The paper aims at development of TiO2, Ca5(PO4)3OH (hydroxyapatite, HA) and their multilayer coatings onto stainless steel, titanium and aluminum substrate using suspension plasma spraying. The total thickness of the coatings was in the range 10 to 150 μm. The suspension on the base of distilled water, ethanol and their mixtures was formulated with the use of fine commercial TiO2 pigment crysta...