The development of an artificial bone graft which can promote the regeneration of fractures or diseased bones is currently the most challenging aspect in bone tissue engineering. To achieve the purpose of promoting bone proliferation and differentiation, the artificial graft needs have a similar structure and composition of extracellular matrix. One-step electrospinning method of biocomposite n...

We report the synthesis of hydroxyapatite (HAp)-based antibacterial biomaterials using a mussel shell as calcium source and by integration silver ions via wet precipitation method. The doping at 2 mol% can provide silver-doped carbonated HAp while 10 mol% offer HAp/silver oxide nanocomposite. synthesized Ag-integrated samples exhibit H (263–903Mpa) E (0.96–3.31GPa) almost similar to cancellous ...

As interest in using carbon nanotubes for developing biologically compatible systems continues to grow, biological inspiration is stimulating new directions for in vivo approaches. The ability to integrate nanotechnology-based systems in the body will provide greater successes if the implanted material is made to mimic elements of the biological milieu especially through tuning physical and che...

INTRODUCTION It is proposed that to satisfy a growing percentage of the population that requires greater than thirty-year survivability of load-bearing bone replacement devices [1], a concept shift, from emphasis on replacement of tissues to regeneration of tissues, is required [2]. Based on the bioactivity of hydroxyapatite (HA) and the excellent mechanical and biocompatible performance of Pol...

This study evaluates the influences of 8DSS peptide and ionic concentrations of simulated body fluid on remineralization behaviors. The polished enamel specimens were acid-demineralized, exposed briefly to 8DSS peptide solution, and then immersed into simulated body fluid (SBF) that favors mineral deposition. At various stages of treatment, nanohardness and elastic modulus were determined by na...

BACKGROUND An engineered tissue structure is an artificial scaffold combined with cells and signaling factors. Among various polymers, the polylactide-co-glycolide/hydroxyapatite (PLGA/HA) has attracted much attention due to their optimal properties. The aim of this study was to study the behavior of human endometrial stem cell (hEnSC)-derived osteoblast cells cultured on PLGA/HA nanocomposite ...

It is known that iron found as a trace element in bone tissue, the main inorganic constituent of which hydroxyapatite. Therefore, iron-doped hydroxyapatite (HApFe) materials could be new alternatives for many biomedical applications. A facile dip coating process was used to elaborate nanocomposite coatings. The HApFe suspension prepare coatings achieved using co-precipitation method, adapted la...

Background: Titanium (Ti) implants are commonly coated with hydroxyapatite (HA). However, HA has some disadvantages such as brittleness, low tensile strength and fracture toughness. It is desirable to combine the excellent mechanical properties of ZrO2 and the chemical inertness of Al2O3 with respect to the purpose of this project which was coating Ti implants with HA-ZrO2-Al2O3 to modify the s...

New nanocomposite membranes with high bioactivity were fabricated using the electrospinning. These nanocomposites combine a degradable polymer poly(L/DL)-lactide and bone cell signaling carbonate nano-hydroxyapatite (n-HAp). Chemical and physical characterization of the membranes using scanning electron microscopy, Fourier transform infrared spectroscopy and the wide angle X-ray diffraction evi...

A simple and sensitive electrochemical sensor fabricated with graphene nanosheets (GNs) and a hydroxyapatite (HA) nanocomposite-modified glassy carbon electrode (GCE) was developed for the determination of matrine (MT). The as-prepared electrode (GNs/HA/GCE) was verified to outperform bare a GCE and GNs-modified electrode with increased oxidation peak currents and the decreased over-potential i...