g-Aminobutyric acidA receptor g-subunits are important for benzodiazepine (BZD) binding and modulation of the g-aminobutyric acid-mediated Cl current. Previously, by using g2/a1 chimeric subunits, we identified two domains of the g2-subunit, Lys-41-Trp-82 and Arg-114-Asp-161, that are, in conjunction, necessary and sufficient for high-affinity BZD binding. In this study, we generated additional...

Application of 4-(aminomethyl)cyclohexanecarboxylic acid (tranexamic acid; TAMCA) to the central nervous system (CNS) has been shown to result in hyperexcitability and convulsions. However, the mechanisms underlying this action are unknown. In the present study, we demonstrate that TAMCA binds to the -aminobutyric acid (GABA) binding site of GABAA receptors in membranes from rat cerebral cortex...

11. Shivers, B. D., Killisch, I., Sprengel, R., Sontheimer, H., Kohler, M., Schofield, P. R. & Seeburg, P. H. (1989) Neuron 3,327-337 Sieghart, W. ( I 989) Trends Pharmacol. Sci. 10,407-41 1 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. (1 988) Neuron I , 937-947 Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P. & Barnard, E. A. ( 1989) Mol. Brain Res. 5,305-3 1...

El objetivo de la presente investigación fue entrenar un grupo jueces en cata café taza. Se llevó a cabo el Laboratorio Evaluación Sensorial Universidad Pamplona. Las muestras suministradas los fueron preparadas acuerdo NTC 4883. La primera etapa del proceso consistió convocar estudiantes programa Ingeniería Alimentos Pamplona para ser candidatos conformar taza; quienes se les aplicaron pruebas...