Objective: The aim of this study was to investigate the toxicity; analgesic and anti-pyretic properties of standardized HA methanolic extract (HAMeOH) in vivo. Methods: The acute toxicity study was performed on rats while adopting the OECD-420 Guidelines (fixed dose procedure). Assessment of analgesic activity was performed in rats with two analgesic models. One was acetic acid induced writhing...

Effects of Hyoscyamus niger L on central nervous system have been known for many years. The effects of methanolic extract of H. niger L. on seizures induced by picrotoxin was studied in mice in this investigation. In this study 7 groups of animals pretreated with methanolic extract of the plant (12.5, 25, 50, 100, 200, 300, 400 mg/kg/i.p.), 20 minutes prior to the picrotoxin (12 mg/kg/ i.p.)--i...

Family Solanaceae is one of the largest families in plant kingdom. A family 98 genera and over 2700 species; tropical temperate; herbs, shrubs or small trees.
 Secondary metabolites plants, sharing tropane skeleton as a common structural feature, sharply divided into two classes: tropine ecgonine derivatives. The first group, represented by well-known alkaloids: atropine scopolamine, which...