A six year old female child with generalized hyperpigmented hyperkeratotic verrucous plaques with nail and dental abnormalities suggestive of ichthyosis hystrix type of epidermal nevus is being reported in view of the rarity of this condition.

We report a familial case of piebaldism affecting a 33-year-old man and his 3-month-old son. Typical skin findings, white forelock and amelanotic white macules containing hyperpigmented macules, were characteristically presented on both patients.

OBJECTIVES To create a dermoscopic classification of atypical melanocytic nevi (Clark nevi) and to investigate whether individuals bear a predominant type. DESIGN Digital dermoscopic images of Clark nevi were classified according to structural features, ie, reticular, globular, or homogeneous patterns or combinations of these types. The nevi were also characterized as central hypopigmented or...

A 55-year-old male developed itching on the anterior aspects of both legs and the right ankle. Gradually over the next 5 years there was thickening of the skin on these areas followed by the appearance of hyperpigmented, scaly, severely itchy plaques. He also noticed the appearance of a thick, hard horn-like structure projecting from the surface of the right ankle lesion for the last 2 years. A...

Previously, split-thickness human skin grafted onto athymic mice has been shown to become markedly hyperpigmented, but the factor(s) responsible for this hyperpigmentation had not been isolated. The present study describes the isolation and characterization of a potent melanogenic inhibitor from grafted human skin. Extracts from grafted skin inhibited, in a concentration-dependent manner, tyros...

Linoleic acid (LA) is known to have a whitening effect on hyperpigmented skin, and is encapsulated in liposomes for topical application because of its low solubility in aqueous solution, although the effect of liposomalization of LA on the whitening activity has not been evaluated. In the present study, we evaluated the effect of liposomalization on the whitening activity of LA by using LA in e...

Mishra K, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222402 Description A 38-year-old man presented with insidious onset, gradually progressive and non-painful swelling over skull since childhood. His parents gave a history of noticing a dark-coloured patch over the right side of the head at birth which increased in size and attained the present form at around puberty and has been static si...

Melasma is a hyperpigmented dermatological condition common in females. Drugs such as steroids, cosmetics, and photosensitizing agents are known to cause melasma. We report here a case of an adult male with obsessive-compulsive disorder, receiving clomipramine, who developed melasma.