SUMMARY Hypophyseal triplication is malformation that has not been described previously. We present a child with midline abnormalities who underwent epignathus excision at birth. Brain MR imaging revealed 2 paired lateral pituitary glands and an oval midline gland, each with an independent stalk, connected to a thickened third ventricle floor. Because malformations represent a failure in embryo...

Early studies of the mammary gland and its innervation led to the belief, at least in some quarters, that mammary activity is under the control of the nervous system.6 With the development of endocrinology, however, growth and function of the mammary apparatus were found to be determined by secretions of the ovaries and hypophysis. In a number of species mammary development identical with that ...

One of the immediate effects of hypophysectomy is a loss of nitrogen (1) and a corresponding loss in weight (2). This change is reflected clinically by the so-called cachexia of Simmonds' disease (3). Nitrogen balance is then re-established at a lower level of body weight with lessened food intake. In the experimental animal, adequate replacement therapy is readily obtained with anterior hypoph...