Whether the motor cortex regulates voluntary movements by generating the motor pattern directly or by acting through subcortical central pattern generators (CPGs) remains a central question in motor control. Using the rat whisker system, an important model system of mammalian motor control, we develop an anesthetized preparation to investigate the interaction between the motor cortex and a whis...

Judicious use of Indigenous Construction Materials (ICM) contributes to sustainability a local construction industry. Why has the ICMs not contributed Ghanaian Industry (GCI), and how can engender GCI that similar developing countries? This paper uses bounded rationality mixed-method strategy explain ICM usage rate in GCI, describes measures for improving industry through use. Relatively high c...

Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimulation in combination with motor rehabilitation. Adult rats were trained to cr...

An interactive case memory (ICM) is a system that interacts with a human user to gather information about a problem, interpret that information and search a store of previous cases to find cases that may be useful in solving the new problem. Many of the commercially successful products that have been derived from research on case-based reasoning could be described as ICMs. ICMs are type of advi...

Mouse blastocysts, aged 0, 2, 6 and 12 h from the onset of cavitation, were examined by transmission (TEM) and scanning (SEM) electron microscopy. In TEM sections, trophectoderm cells (TE) differed morphologically from those of the inner cell mass (ICM) by their flattened shape, paler cytosol staining and polarized disposition of both junctional complexes (apicolateral) and intracellular second...

Systemic infections caused by Salmonella enterica are an ongoing public health problem especially in Sub-Saharan Africa. Essentially typhoid fever is associated with high mortality particularly because of the increasing prevalence of multidrug-resistant strains. Thus, a rapid blood-culture based bacterial species diagnosis including an immediate sub-differentiation of the various serovars is ma...

In contrast to the high degree of experience-dependent plasticity usually exhibited by cortical representational maps, a number of experiments performed in visual cortex suggest that the basic layout of orientation preference maps is only barely susceptible to activity-dependent modifications. In fact, most of what we know about activity-dependent plasticity in adults comes from experiments in ...

We trained two monkeys to perform a fixation task. Intracortical microstimulation (ICMS) was applied to the monkey frontal eye field (FEF) while monkeys were fixating on one of five fixation LEDs. The ICMS was applied in two different manners. Under the single stimulation condition, ICMS was delivered to either right or left FEF. Under the paired stimulation condition, bilateral FEF were succes...

Recent trends in synthetic biology to move from prototypes to applications have triggered higher expectations on the robustness, predictability and responsiveness of biomolecular circuits. Therefore, a systematic approach to designing biomolecular controllers for regulating gene expression is needed. Although a number of integral control motifs (ICMs) have been proposed for set-point regulation...

Modelling frameworks provide models with support components that handle tasks such as visualisation, data management and model integration. Within these broad requirements different approaches to framework development are possible. Tarsier is a modelling framework that supports the development of models in a high level language, such as C++. This approach allows Tarsier model developers to craf...