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Background Infants of diabetic mothers (IDMs) have significantly greater risk for spontaneous abortion, stillbirth, congenital malformations and perinatal mortality and morbidity but whether maternal DM affects the neonatal innate immune system is unknown. We aimed to assess the immune response of infants of diabetic mothers (IDMs) with non-gestational DM for Hepatitis B vaccine and to compare ...

Three types of hepatitis are seen in children-acute viral hepatitis, active chronic hepatitis and the neonatal hepatitis syndrome. Few adequate controlled clinical trials of immunosuppressive therapy have been performed in these conditions, and none specifically in children. Many trials in the 1950s using corticosteroids were performed in acute viral hepatitis. Some showed that steroids were su...

Hyper IgD syndrome (HIDS) is a rare metabolic autoinflammatory syndrome characterised by recurrent febrile episodes, accompanied by various inflammatory symptoms. We present a case of severe HIDS in a young girl, whose symptoms started in the neonatal period with hepatomegaly, hepatitis, thrombocytopenia, and conjugated hyperbilirubinemia. From the age of five months, the child had recurrent fe...