نتایج جستجو برای: idiopathic parkinson disease
تعداد نتایج: 1538852 فیلتر نتایج به سال:
OBJECTIVES We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). METHODS We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, S...
primary immune thrombocytopenia is an acquired bleeding disorder with no clinically apparent cause of thrombocytopenia. clinical indicators of itp include easy bruising of the skin, prolonged bleeding on injury, mucocutaneous lesions such as petechiae and ecchymosis, epistaxis, gastrointestinal bleeding, hematuria and bleeding from the gums. it is important for a dentist to be aware of the clin...
Abstract Background Parkinsonism is frequently observed in patients with schizophrenia, and most are diagnosed drug‐induced parkinsonism. However, comorbidity idiopathic Parkinson's disease or Parkinson‐plus syndrome also possible. The pathophysiology treatment for each of these entirely different, thus an appropriate diagnosis required. distinguishing them based on clinical symptoms alone ofte...
since its first description of botulism toxicity in 1820s, specific formulations of botulinum neurotoxin (bont) have been introduced with different clinical benefits. however, there is increasing number of adverse events reported to food and drug administration. this report presents the case of 62-year-old woman with parkinson’s disease who received bont injections to treat painful spasticity i...
background: vitamin d is an important factor responsible for many physiologic functions. vitamin d deficiency is associated with increased risk of neurodegenerative disease. the level of vitamin d in iranian patients with parkinson's disease and its relationship with severity of symptoms and signs were evaluated in this study. methods: eighty-three patients with parkinson's disease (pd) were re...
introduction: one of the most common syndromes in parkinson's disease (pd) is rigidity. currently, an index is used to evaluate the level of pd by the clinical measurement of rigidity in the upper extremity. the index uses a subjective method called unified parkinson's disease rating system (updrs). the subjective nature of this method makes the influence of physician in the measureme...
α-Synuclein is a key driver of the pathogenesis Parkinson disease (PD). Heme oxygenase-1 (HO-1), stress protein that catalyzes conversion heme to biliverdin, carbon monoxide and free ferrous iron, elevated in PD-affected neural tissues promotes iron deposition mitochondrial dysfunction models disease, pathways also impacted by α-synuclein. Elevated expression human HO-1 astrocytes GFAP.HMOX1 tr...
Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is spared. This constitutes the first lesion observation congruent with the anat...
Research into the causes of Parkinson disease (PD) has accelerated recently with the discovery of novel gene mutations. The majority of PD cases, however, remain idiopathic and in those cases environmental causes should be considered. Several recent reports have focused on welding and manganese toxicity as potential risk factors for parkinsonism and some have even proposed that welding is a ris...
This proposal builds upon a well-established foundation of experimental data demonstrating the efficacy of LVST to help individuals with Idiopathic Parkinson Disease and the power of conversational interaction with animated agents to help individuals learn. This fit between ongoing work at LSVT and CSLR offers an unprecedented opportunity to demonstrate the efficacy of speech treatment enhanced...
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