As opposed to the treatment landscape for myelodysplastic syndromes (MDS) two decades ago, potential therapies now abound for the treatment of lower-risk and higher-risk populations. In lower-risk patients, decision tools can be used to determine the likelihood of response to erythropoiesis stimulating agents (ESAs), which have demonstrated survival advantages in retrospective studies in patien...

Chronic Lymphocytic Leukemia (CLL) is a disease of the elderly: almost 70% of diagnoses are made in patients older than 65 years. This indolent lymphoproliferative disorder, manifested by a clonal expansion of mature but functionally defective lymphocytes, is one of the most common leukemias of adults in Western countries. The incidence rate is roughly 2-6 cases per 100,000 persons per year, an...

There has been plenty of research concerning the representation of voluntary action in the human brain. However, the question of how we represent the voluntary omission of an action has been largely neglected. Therefore this study aimed at investigating the representation of intentionally not doing something by means of event-related potentials (ERPs). Free-choice nonactions elicit similar evok...

Macroscopic objects appear to have definite positions. In a manyworlds interpretation of quantum theory, this appearance is an illusion; the correct view is the “view from outside” in which even macroscopic objects are in general in a superposition of different positions. In the Bohm model, objects really are in definite positions. This additional aspect of reality is accessible only from the “...

It is a central aspect of our ordinary concept of time that history unfolds and events come into being. It is only natural to take this seriously. However, it is notoriously difficult to explain further what this ‘becoming’ consists in, or even to show that the notion is consistent at all. In this article I first argue that the idea of a global temporal ordering, involving a succession of cosmi...

anaging risk is not optional for organizations. Clause 0.1 of ISO 9004 mentions risk management in the same breath with cost and benefit considerations as being important to an organization, its customers and interested parties. Clause 5.4.2 also includes risk assessment and mitigation data as necessary inputs for efficient and effective quality planning. Some sectors, particularly aerospace an...