Serum IgE concentrations were determined and IgE turnover studies were performed in control individuals as well as in patients with several disease states. Patients with common variable hypogammaglobulinemia, thymoma and hypogammaglobulinemia, ataxia telangiectasia, and selective IgA deficiency had significantly decreased mean serum IgE concentrations. In turnover studies, this was found to be ...

The manifestations of allergic disorders are closely tied to the biologic effects of IgE activation with Ag. In immediate hypersensitivity reactions, IgE effector function requires prior binding to innate immune cells, primarily mast cells and basophils, with the blood acting as a reservoir for unbound IgE. As the severity of allergic disease is proportional to the size of this unbound IgE pool...

Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab-Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively binds free IgE. The structure of the complex also provides mecha...

objective: the prevalence of respiratory allergies, especially those induced by fungi such as alternaria alternata, has dramatically increased over the past decade. this increase has caused major health problems worldwide. this study aimed to investigate the role of a. alternata in the etiology of allergic asthma, by using the skin prick test and assessment of ige specific to the fungus in the ...

emerging data suggest that measurement of serum ige to peanut components can be clinically helpful and more accurate than ige to whole peanut to predict peanut allergy. not all studies have used prospective samples, multiple components and oral challenges. currently, there are no data on this topic involving italian children. 32 patients (23 males; median age 9 years) with reported history for ...