Fetal and neonatal alloimmune thrombo cytopenia (FNAITP) is a life-threatening bleeding disorder caused by maternal antibodies directed against fetal platelet antigens. The immunoreactive epitopes in FNAITP are primarily located in the extracellular regions of the platelet glycoprotein IIIa (beta3 integrin). Here we have established a novel animal model of FNAITP using beta3 integrin-deficient ...

During canine leishmaniasis (CanL) due to Leishmania infantum, high levels of antibodies production are associated with the presence of various clinical signs, because of the deposition of soluble immune complexes in organs and tissues. The immunofluorescence antibody test (IFAT) is one of the most commonly used techniques for detection of anti-Leishmania antibodies. The purpose of this study w...

T h e antibodies that are p roduced in man as a result of specific vaccination or infectious disease comprise only a small propor t ion o f the bulk o f the IgG molecules circulating in the blood. T h e immunity towards these antigens is a t t r ibuted mostly to a relatively high n u m b er o f memory cells and a low titer o f synthesized antibodies. In view of kinetic studies o f ant ibody pro...

Background: Group O blood donor is more readily available and frequently used as a universal red cell emergency whole (EM O) for exchange transfusion in neonates. Sera from group donors contains two separable haemolysin antibodies, anti-A anti-B, cross-reacting antibody called anti-A, B (mostly IgG). The presence of haemolysins the may lead to haemolysis recipients. Objectives: This study aims ...

The UspA1 and UspA2 proteins from Moraxella catarrhalis share antigenic epitopes and are promising vaccine candidates. In this study, the levels and bactericidal activities of antibodies in sera from healthy adults and children toward UspA1 and UspA2 from the O35E strain were measured. Human sera contained antibodies to both proteins, and the levels of immunoglobulin G (IgG) antibodies were age...

background: it seems that the incidence of pertussis-like illnesses is considerably increasing despite the wide coverage of immunization with the whole cell pertussis vaccine. we aimed to investigate the occurrence of pertussis in vaccinated children by measuring anti-pertussis antibodies. methods: in this cross-sectional study, blood samples were taken from vaccinated children aged 2, 4, 6, 12...

Abstract Millions of individuals who have recovered from SARS-CoV-2 infection may be eligible to participate in convalescent plasma donor programs, yet the optimal window for donating high neutralizing titer COVID-19 immunotherapy remains unknown. Here we studied response trajectories antibodies directed surface spike glycoprotein and vitro live virus titers (VN) 175 donors longitudinally sampl...

Recently it has been reported, that immunoglobulin Y (IgY) can be used instead of polyclonal antibodies extracted from mammals (IgG) for the purpose of diagnosis and therapy. These antibodies are found to have better properties in terms of specificity and ease of large-scale production. In addition, IgY binds neither to mammalian complement or Fc-receptors nor does it interfere with rheumatoid ...