Type 2 diabetes (T2D) can go undiagnosed for years, leading to a stage where chronic high blood sugar produces complications such as delayed wound healing. Reports have shown that BLT2 activation improves keratinocyte migration and wound healing, as well as protecting the epidermal barrier through the promotion of actin polymerization. The goal of this study was to elucidate the role of BLT2 ex...

Psoriasis is a chronic inflammatory skin disease caused by an IL-23- and IL-17 driven immune response. Monocytes are regarded as key regulatory cells, which can be divided into three well-defined subsets: classical monocytes, intermediate non-classical monocytes (ncMo). The function of ncMo in inflammation remains largely unknown. Yet, our previous studies on slan+ (6-sulfo LacNAc) suggested th...

Cholesteatoma is a severe non-cancerous lesion of the middle ear characterized by massive inflammation, tissue destruction, and an abnormal growth keratinized squamous epithelium. We recently demonstrated presence pathogenic stem cells within cholesteatoma tissue, unfortunately their potential roles in regulating disease-specific chronic inflammation remain poorly understood. In presented study...

Obesity is now recognized as a global health problem and has reached epidemic proportions, affecting both developed developing countries. This condition associated with an increased incidence in central nervous system (CNS) disorders. The intake of foods or supplements anti-inflammatory activity could potentially lead to lower impact obesity on the functionality CNS. Therefore, this work we tes...

We describe for the first time a case of macrophage activation syndrome (MAS) in a patient with a history of inflammatory myofibroblastic tumour (inflammatory pseudotumour, IPT) of the lung and thoracic spine. The patient was admitted to the intensive care unit with a history of prolonged remitting fever, hepatosplenomegaly, bilaterally enlarged thoracic lymph nodes and an acute severe inflamma...

We describe for the first time a case of macrophage activation syndrome (MAS) in a patient with a history of inflammatory myofibroblastic tumour (inflammatory pseudotumour, IPT) of the lung and thoracic spine. The patient was admitted to the intensive care unit with a history of prolonged remitting fever, hepatosplenomegaly, bilaterally enlarged thoracic lymph nodes and an acute severe inflamma...

Hidradenitis Suppurativa (HS) is an autoinflammatory skin disease characterized by painful, pruritic nodules, abscesses and pus-draining tunnels in intertriginous skin. To better elucidate the immune response leading to localized activity HS skin, we compared cytokines from 15 lesional perilesional biopsies patients with Hurley Stage II III HS. Patients additionally filled out a qualitative que...