Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...

In medicinal chemistry nitrogen containing heterocycles are the most important compounds which show various biological activities. The cinnoline are nitrogenous derivatives and found to elicit many pharmacological actions like anti-hypertensive, antithrombotic, antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and antisecretory activity. We planned to synthesis new series of ...

From few decades, fused heterocyclic chemistry has occupied a prominent place in Medicinal Chemistry. Moreover, fused imidazole systems have attracted the researcher’s interest due to their natural occurrence and significant medicinal applications [1-3]. Additionally, the benzimidazole derivatives are the bioisosters of natural nucleotides, which can interact easily with the macromolecules (pro...