The key steps in most organocatalytic cyclizations are the reactions of electrophiles with nucleophiles. Their rates can be calculated by the linear free-energy relationship log k(20 °C) = s(N)(E + N), where electrophiles are characterized by one parameter (E) and nucleophiles are characterized by the solvent-dependent nucleophilicity (N) and sensitivity (s(N)) parameters.Electrophilicity param...

Piperazine derivatives have been identified as new antidiabetic compounds. Structure-activity relationship studies in a series of 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines resulted in the identification of 1-methyl-4-(2', 4'-dichlorobenzyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazine, PMS 812 (S-21663), as a highly potent antidiabetic agent on a rat model of diabetes, ...

Pentacoordinated iridium( i )-cyclooctadiene complexes featuring a coumarin-functionalised imidazoline– or benzimidazoline–NHC ligand exhibit fluxional behavior as consequence of the hemilability pyrone ring in coumarin wingtip.

The paper discusses syntheses of new nitroxides by structure modifications of known carbocyclic and heterocyclic nitroxides and their diamagnetic precursors, as well a6 syntheses of nitroxides with a functional group in close proximity to the radical centre. It demonstrates a new route to pyrrolidine nitroxides. Much has been focused on 3-imidazoline and 3-imidazoline-3-oxide nitroxides owing t...

Transient precursor states are often experimentally observed for molecules adsorbing on surfaces. However, such precursor states are typically rather short-lived, quickly yielding to more stable adsorption configurations. Here we employ first-principles calculations to systematically explore the interaction mechanism for benzene derivatives on metal surfaces, enabling us to selectively tune the...

Effects of agmatine, an endogenous metabolite formed by decarboxylation of L-arginine, on ethanol-induced gastric mucosal injury were investigated in rats. Agmatine at 1 and 10 mg/kg i.p doses significantly increased ethanol-induced gastric mucosal injury. This effect of agmatine was abolished completely by pretreatment with idazoxan, an imidazoline receptor-antagonist and alpha2 receptor- anta...

An< accurate, stable and very fast corner finder (for feature based vision) has been developed', based on a novel definition of corners, using:no image derivatives. This note describes the algorithm and the results obtained from its use.