Cross-coupling of aromatic aldehydes or benzoins with unactivated imines catalyzed by an N-heterocyclic carbene (NHC) affords alpha-amino ketones smoothly.

The dirhodium caprolactamate [Rh(2)(cap)(4)] catalyzed oxidation of secondary amines to imines by tert-butyl hydroperoxide (TBHP) occurs with high chemo- and regioselectivity.

The first highly enantioselective catalytic method for the preparation of chiral aminals via the addition of imide nucleophiles to imines is reported.

The aza-Friedel–Crafts (aza-FC) reaction is a very powerful tool for forming C–C and C–N bonds, based on an acid-catalyzed addition of electron-rich aromatic compounds to imines.

The first example of palladium-catalyzed decarboxylative 1,2-addition of carboxylic acids to aldehydes or imines under mild conditions is described.

Chiral nitrogen-containing compounds are widely distributed in nature and include many biologically important molecules (Chart 1). In these compounds, the nitrogen-containing units are known to play important roles for their bioactivities. For the synthesis of these chiral nitrogen-containing building blocks, use of imines as electrophiles is the most promising and convenient route.1 While many...

Polymethylhydrosiloxane, when combined with titanium(IV) isopropoxide, provided a convenient system for the conversion of esters to the corresponding primary alcohols in the presence of a wide range of functional groups. Reactions were carried out as mixtures of the neat reaction components; work-up with aqueous alkaline THF afforded primary alcohols in good to excellent yields. The system tole...

An extended study of the scope and mechanism of the catalytic asymmetric aziridination of imines with ethyl diazoacetate mediated by catalysts prepared from the VANOL and VAPOL ligands and triphenylborate is described. Nonlinear studies with scalemic VANOL and VAPOL reveal an essentially linear relationship between the optical purity of the ligand and the product suggesting that the catalyst in...

A Lewis base-Brønsted acid co-catalyzed Morita-Baylis-Hillman reaction of cyclic sulfamidate imines with acrylate-type Michael acceptors has been developed. The combination equimolecular catalytic amounts DABCO and acetic proved highly efficient tolerated well a wide range substituted 6-membered ring imines, as sultam derivative. provides straightforward access to sulfamidates bearing ?,?-unsat...

Dipropargyl amines are synthesized by a double direct alkynylation of primary followed by secondary imines formed in situ during an efficient, five-component, one-pot coupling reaction cocatalyzed by ruthenium and copper in water.