نتایج جستجو برای: immune suppressors

تعداد نتایج: 270947  

Journal: :The Plant cell 2012
Qing Kong Na Qu Minghui Gao Zhibin Zhang Xiaojun Ding Fan Yang Yingzhong Li Oliver X Dong She Chen Xin Li Yuelin Zhang

In Arabidopsis thaliana, the MEKK1-MKK1/MKK2-MPK4 mitogen-activated protein (MAP) kinase cascade represses cell death and immune responses. In mekk1, mkk1 mkk2, and mpk4 mutants, programmed cell death and defense responses are constitutively activated, but the mechanism by which MEKK1, MKK1/MKK2, and MPK4 negatively regulate cell death and immunity was unknown. From a screen for suppressors of ...

2013
Hong W. H. Yu Daniel M. Y. Sze William C. S. Cho

MicroRNAs (miRNAs) are a category of small RNAs that constitute a new layer of complexity to gene regulation within the cell, which has provided new perspectives in understanding cancer biology. The deregulation of miRNAs contributes critically to the development and pathophysiology of a number of cancers. miRNAs have been found to participate in cell transformation and multiplication by acting...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1977
D Turkin E E Sercarz

The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific, and anti-theta sensitiv...

2013
Suk Ji Youngnim Choi

Periodontitis is a chronic inflammation of periodontal tissue caused by subgingival plaque-associated bacteria. Periodontitis has long been understood to be the result of an excessive host response to plaque bacteria. In addition, periodontal pathogens have been regarded as the causative agents that induce a hyperinflammatory response from the host. In this brief review, host-microbe interactio...

Journal: :The Journal of biological chemistry 2015
Lin Yuan Zhongbin Chen Shanshan Song Shan Wang Chunyan Tian Guichun Xing Xiaojuan Chen Zhi-Xiong Xiao Fuchu He Lingqiang Zhang

Infection by human coronaviruses is usually characterized by rampant viral replication and severe immunopathology in host cells. Recently, the coronavirus papain-like proteases (PLPs) have been identified as suppressors of the innate immune response. However, the molecular mechanism of this inhibition remains unclear. Here, we provide evidence that PLP2, a catalytic domain of the nonstructural ...

2015
Douglas Hanahan Robert A. Weinberg

The hallmarks of cancer comprise eight biologic capabilities acquired by incipient cancer cells during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing an...

Journal: :In vivo 2006
Ralph Pries Annette Thiel Carsten Brocks Barbara Wollenberg

BACKGROUND Cytokine profiles of permanent cell lines of head and neck squamous cell carcinoma (HNSCC) were analyzed to define the cytokine levels secreted in the absence of immune cells. MATERIALS AND METHODS Cytokine profiles of IL-4, IL-6, IL-8 and IL-10 were analyzed in the supematants of 4 different permanent HNSCC cell lines using the Bio-Plex human cytokine assay system. RESULTS In HN...

ژورنال: ارمغان دانش 2022

Background and aim: Aberrant activation of diverse intracellular signaling pathways involved in differentiation, cell growth, apoptosis. These pathways include known oncogenic pathways such as Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway. The JAK/STAT signaling pathway plays an important role in many cellular functions. This pathway can be activated by variou...

2009
Megan E. Rokop Alan D. Grossman

BACKGROUND The Bacillus subtilis genes dnaD and dnaB are essential for the initiation of DNA replication and are required for loading of the replicative helicase at the chromosomal origin of replication oriC. Wild type DnaD and DnaB interact weakly in vitro and this interaction has not been detected in vivo or in yeast two-hybrid assays. METHODOLOGY/PRINCIPAL FINDINGS We isolated second site ...

Journal: :Genetics 1993
B A Fane S Shien M Hayashi

This report describes the isolation and characterization of second-site suppressors of a cold-sensitive (cs) external scaffolding protein, gpD, of bacteriophage phi X174. Seven genetically distinct suppressors were isolated. Six of them are located in gene F which encodes the major coat protein of the virus. The seventh is located in gene J which encodes the DNA-binding protein. A subset of the...

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