نتایج جستجو برای: immunoglobulin isotypes
تعداد نتایج: 67668 فیلتر نتایج به سال:
938 Human Vaccines & Immunotherapeutics Volume 9 Issue 4 Table 1 in the article incorrectly identifies the isotype of monoclonal antibodies that are used in stability indicating assays that support the Gardasil product line. Corrections to Table 1, revised Feb 2012, correct 2 mAb isotype designation H16.J4 = IgG2a and H18. J4 = IgG2a, see corrected table below. Correction to: Smith JF, et al. H...
B lymphocytes use B cell receptors (BCRs) to sense the physical features of the antigens. However, the sensitivity and threshold for the activation of BCRs resulting from the stimulation by mechanical forces are unknown. Here, we addressed this question using a double-stranded DNA-based tension gauge tether system serving as a predefined mechanical force gauge ranging from 12 to 56 pN. We obser...
the HI assay can be influenced by non-specific serum inhibitors the reactivity of both HI and SN assays strongly depends on the test virus strain used (homologous or heterologous strains) 1 . HI titers show a peak 2-3 weeks after experimental infection. After a maximum of 22 weeks, these titers decrease and become negative, while ELISA still may give positive resultats 3 . Indirect ELISAs seem ...
Antibodies are a highly successful class of biological drugs, with over 50 such molecules approved for therapeutic use and hundreds more currently in clinical development. Improvements in technology for the discovery and optimization of high-potency antibodies have greatly increased the chances for finding binding molecules with desired biological properties; however, achieving drug-like proper...
Members of the mammalian protein kinase C (PKC) superfamily play key regulatory roles in a multitude of cellular processes, ranging from control of fundamental cell autonomous activities, such as proliferation, to more organismal functions, such as memory. However, understanding of mammalian PKC signalling systems is complicated by the large number of family members. Significant progress has be...
Plant actins are encoded by a gene family. Despite the crucial significance of the actin cytoskeleton for plant structure and function, the importance of individual actin isotypes and their specific roles in various plant tissues or even single cells is rather poorly understood. This review summarizes our current knowledge about the plant actin gene family including its evolution, gene and prot...
A surface receptor specific for human IgA on group B streptococci possessing the Ibc protein antigen
A number of group B streptococcal strains of various serotypes, Ia, Ib, Ic, II, and III were examined for their ability to bind human IgG and IgA. No strains of group B streptococci were found to bind IgG, but many strains possessing the Ibc protein antigen(s) were found to bind a significant amount of IgA. The extent of IgA binding correlated with the amount of a 130,000 mol wt, detergent-extr...
The holotypes and isotypes of 20 Hypoxylon taxa described by Spegazzini have been examined and their taxonomic positions and nomenclatural problems are discussed. Two new combinations, Annulohypoxylon apiahynum comb. nov. and A. subeffusum comb. nov., are proposed. H. goliath is considered a synonym of Rosellinia bunodes. H. albostigmatosum and H. guarapiense are synonyms of H. anthochroum, H. ...
Bimolecular fluorescence complementation was used to engineer CD8 molecules so that CD8αα and CD8αβ dimers can be independently visualized on the surface of a T cell during antigen recognition. Using this approach, we show that CD8αα is recruited to the immunological synapse almost as well as CD8αβ, but because the kinase Lck associates preferentially with CD8αβ in lipid rafts, CD8αα is the wea...
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