نتایج جستجو برای: immunologic cytotoxicity

تعداد نتایج: 75008  

Journal: :Human immunology 2011
Francesca Poli Elena Benazzi Annalisa Innocente Angela Nocco Nicoletta Cagni Andrea Gianatti Roberto Fiocchi Mario Scalamogna

The development of solid-phase assays for antibody detection has aided in the frequent detection of human leukocyte antigen (HLA) antibodies in nonalloimmunized males. Some scientists have reported that these HLA antibodies are produced to pathogens or allergens and the reactivity with HLA coated beads is the result of cross-reactive epitopes. These antibodies may also be directed toward crypti...

2015
Kimberly H. Harrington Chelsea J. Gudgeon George S. Laszlo Kathryn J. Newhall Angus M. Sinclair Stanley R. Frankel Roman Kischel Guang Chen Roland B. Walter Ken Mills

The CD33/CD3-bispecific T-cell engaging (BiTE) antibody construct, AMG 330, potently lyses CD33+ leukemic cells in vitro. Using specimens from 41 patients with acute myeloid leukemia (AML), we studied the factors that might contribute to clinical response or resistance. For this purpose, thawed aliquots of primary AML samples were immunophenotypically characterized and subjected to various dose...

Journal: :Journal of Investigative Dermatology 1990

Journal: :American journal of obstetrics and gynecology 1969
H A Cabrera

2 biologic and 7 immunologic pregnancy tests were evaluted on the basis of results obtained over a 10-year period. The test evaluated were the Friedman test, the rat ovarian hyperemic test, the urinary chorionic gonadotropin test, the Pregnosticon tube test, the Gravindex slide test, the Pregslide test, the HCG test and the Pregnosticon slide test. The biologic tests were found to be superior ...

Journal: :Infection and immunity 1975
R M Austin C A Daniels

Interaction of staphylococcal protein A (SPA) with human serum depressed the ability of such serum to neutralize herpes simpled virus (HSV)-antibody labialis. SPA-induced depression of serum-dependent virus neutralization appeared to be due to consumption of complement by SPA. In addition, SPA attached to antibody-treated, HSV-infected cells and inhibited complement mediated immune cytolysis. T...

Journal: :Journal of immunology 1984
S Kohl T A Springer F C Schmalstieg L S Loo D C Anderson

Four children with an immunodeficiency involving the absence of leukocyte membrane glycoproteins reacting with anti-LFA-1 and OKM-1 monoclonal antibodies were unable to mediate adherence-dependent leukocyte functions. Even with normal Fc receptor function, their PMN-ADCC and MC-NKC were markedly deficient. Single cell analysis demonstrated deficient antibody-mediated PMN-target cell adherence. ...

Journal: :Blood 2013
Takuji Yamauchi Katsuto Takenaka Shingo Urata Takahiro Shima Yoshikane Kikushige Takahito Tokuyama Chika Iwamoto Mariko Nishihara Hiromi Iwasaki Toshihiro Miyamoto Nakayuki Honma Miki Nakao Takashi Matozaki Koichi Akashi

Current mouse lines efficient for human cell xenotransplantation are backcrossed into NOD mice to introduce its multiple immunodeficient phenotypes. Our positional genetic study has located the NOD-specific polymorphic Sirpa as a molecule responsible for its high xenograft efficiency: it recognizes human CD47 and the resultant signaling may cause NOD macrophages not to engulf human grafts. In t...

2018
Maxence Duchemin Marwa Khamassi Lin Xu Daniela Tudor Morgane Bomsel

Citation: Duchemin M, Khamassi M, Xu L, Tudor D and Bomsel M (2018) IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis. Front. Immunol. 9:244. doi: 10.3389/fimmu.2018.00244 iga Targeting human immunodeficiency Virus-1 envelope gp41 Triggers antibody-Dependent cellul...

Journal: :Journal of Clinical Investigation 1974

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