Cardiac transplantation offers definitive therapy for selected patients with end-stage heart failure and thus provides significant improvements in survival in these recipients. Heart transplantation comes with a cost, however, resulting from the actual transplantation procedure, the subsequent allo-immune response to the transplant and the immunosuppressive medications required to keep the allo...

Survival after lung transplantation is less than 50% after 5 yrs and is limited by infection and obliterative bronchiolitis. There is, therefore, a need for new immunosuppressive regimens if we are to attempt to improve long-term survival. Several trials in lung transplantation of new immunosuppressive agents are in the planning stages. In this article, we review the experience with a new monoc...

Daphnetin, a plant-derived dihydroxylated derivative of coumarin, is an effective compound extracted from a plant called Daphne Korean Nakai. Coumarin derivates were known for their antithrombotic, anti-inflammatory, and antioxidant activities. The present study was aimed to determine the immunosuppressive effects and the underlying mechanisms of daphnetin on concanavalin A (ConA) induced T lym...

THE RESULTS of kidney transplantation in AfricanAmericans have improved with oetter immunosuppressive regimens. but the overall graft survival is reported by many to be inferior to that of non-Black recipients. 13 The underlying impact of such factors as HLA matching. immunosuppressive regimes. socioeconomic status. or center effect has remained in question as many examine the underlying cause ...

balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...

background: the pathogenesis of many diseases is correlated to irregularity in vascular endothelial growth factor (vegf) expression. results from several association studies show that variation in the level of vegf expression is related to polymorphic sequences within the vegf gene. additionally, there are many studies showing that some gene polymorphisms significantly influence the pharmacokin...

Interleukin-6 is pro-inflammatory cytokine which plays a role in storm and brought into notice with corona virus disease of 2019. Lymphopenia dysregulated immune response were seen the critically ill patients IL-6 inhibitors proposed as treatment option this pandemic concept that it will reduce inflammation, infection organ failure. Tocilizumab, monoclonal antibody against soluble membrane IL‐6...

Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, and the target of immunosuppressive agent tacrolimus (TAC). The dysfunction of calcineurin, or clinical applications of tacrolimus, have been reported to be associated with dyslipidemia. The underlying mechanisms of calcineurin and tacrolimus in lipid metabolism are largely unknown. Here, we showed that mut...