نتایج جستجو برای: immunosuppressive therapy
تعداد نتایج: 667447 فیلتر نتایج به سال:
Therapeutic drug monitoring (TDM) of immunosuppressive drugs has evolved over the last few decades. The use of liquid chromatography–tandem mass spectrometry, for example, now provides robust and highly specific quantification in the clinical laboratory. Nevertheless, the measurement of immunosuppressive drug concentrations, even if carried out accurately and precisely, does not sufficiently re...
Recent advances in immunosuppressive drug regimens have changed the outcome after liver transplantation significantly in the last two decades. However, chronic rejection and long-term graft survival remains a major problem. Side effects like drug-induced nephrotoxicity, hypertension, osteoporosis, hyperlipidaemia and neuropathy of some immunosuppressive agents play an essential role in long-ter...
An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations. After commencement of immunosuppressive therapy reciprocal changes occurred in response to alterations in doses of the medications. Subacutely evolving and spreading muscle weakness developed during tapering ...
Background and Aim: Pemphigus is one of the most common types of autoimmune blistering disease that requires systemic immunosuppressive therapy. Immunosuppressive therapy has improved the disease outcome in recent decades, but long-term use of them has side effects. Recently, it has been tried to evaluate immunosuppressive drugs with less side effects. One of them is mycophenolate mofetil. The ...
BACKGROUND Pemphigus vulgaris (PV) patients receiving immunosuppressive therapy may develop nail alterations resulting from infection, skin disorder, or drug regimen. OBJECTIVE This study aims to describe nail changes in PV female patients receiving immunosuppressive therapy and to report the frequency of associated fungal and bacterial growth in the patients' nails. METHODS Twenty-five fem...
Immunosuppressive therapy was used in seven hemophiliac and three nonhemophiliac patients with factor VIII inhibiors. Permanent disappearance of the inhibitor occurred in three hemophiliac and two nonhemophiliac patients following treatment with cyclophosphamide and factor VIII. Critical factors influencing the response to therapy may include both the titer and duration of the inhibitor and the...
The mainstay of pharmacologic therapy in patients with inflammatory myositis is corticosteroid and sometimes immunosuppressive drugs. However, because patients sometimes become refractory to these drugs and since these drugs have potential short and long-term toxicities, an alternate therapy is highly desirable. Therefore, a pilot study was initiated using intravenous gammaglobulin(IV...
Background: Long term use of immunosuppressive therapy in transplant recipients in order to prevent acute and chronic rejection increases the long term risk of cancer. This study evaluates the incidence of different organs’ cancer after renal transplantation and immunosuppressive therapy. Methods: This is a retrospective analysis of malignant tumors in renal graft recipients with more than...
The current treatment approach for severe aplastic anemia in children is based on studies performed in the 1980s, and updated evidence is required. We retrospectively compared the outcomes of children with acquired severe aplastic anemia who received immunosuppressive therapy within prospective trials conducted by the Japanese Childhood Aplastic Anemia Study Group or who underwent bone marrow t...
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