The corpus callosum of many but not all BALB/c mice is either abnormally small or absent. The basis for the defect is hereditary, but the proportion of mice expressing the anomaly can be modified by changing the early environment. The present study investigated the effects of an F1 hybrid maternal environment, which is known to promote better fetal development than an inbred environment, on bod...

Mouse chimaeras made by aggregating two 8-cell stage embryos undergo size regulation shortly after implantation. Thus chimaeric pups are approximately normal size at birth despite their origin from two complete embryos. Chimaeras of some strain combinations are genotypically unbalanced such that cells of one strain almost always predominate. For example, the BALB/c inbred strain often makes a l...

As background for a serological definition of the unique antigens of chemically induced sarcomas, we have typed a series of fibroblast and sarcoma cell lines of BALB/c and C57BL/6 origin by cytoxicity and absorption tests for murine leukemia virus (MuLV)-related cell surface antigens and known alloantigens. 7 of the 17 cultured lines expressed the range of cell surface antigens associated with ...

Inbred strains of mice were infected intraperitoneally with Coccidioides immitis, and the mean lethal dose was determined after 28 days. DBA/2N mice had a mean lethal dose of greater than 10(5) arthroconidia, whereas BALB/cAnN, C57BL/6N, and C57L/J mice had a mean lethal dose of less than or equal to 10(3). Since both BALB/c and DBA/2 mice are the H-2d haplotype, resistance is not primarily det...

Random-bred Swiss mice were selectively bred for 16 generations; selection was based on their agglutinin response to sheep and pigeon erythrocytes to produce a high and a low responder line. The serum levels of individual immunoglobulins differed significantly in these two lines before immunization. The differences in the levels of immunoglobulins were much more marked after immunization with p...

Susceptibilities of 5 different mice strains, including C3H/HeN, BALB/c, C57BL6, FvB and ICR, to Echinostoma hortense infection, was evaluated. The worm expulsion rate, worm size and egg production were observed from 1 to 8 weeks after infection with 30 metacercariae. C3H/HeN and ICR mice showed the highest worm maturation rates. The worm recovery rate and the number of eggs per gram (EPG) of f...

We have infected BALB/c and C57BL/6 mice with a cloned Leishmania mexicana amazonensis population, obtained from the "Maria" strain. Progression of infection and histopathological examination confirmed the extreme susceptibility of BALB/c mice and the resistant pattern of the C57 BL/6. Anti-Leishmania antibody titers were higher in BALB/c than in C57BL/6 mice through the period of infection. Te...

Over one million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed annually in the United States, and approximately 4% patients develop metastases 2% die. Yet, there is a paucity clinically relevant cSCC murine models. Outbred SKH-1 mice highly susceptible to solar simulated light (SSL)-induced cSCC. However, an outbred strain limits ability evaluate MHC-restricted, antigen-specif...

Substantial variability exists in collateral density and ischemia-induced collateral growth among species. To begin to probe the underlying mechanisms, which are unknown, we characterized two mouse strains with marked differences in both parameters. Immediately after femoral artery ligation, collateral and foot perfusion were lower in BALB/c than C57BL/6 (P < 0.05 here and below), suggesting fe...

The 5'-upsteam region of the genomic gene and cDNA encoding interleukin 4 (IL-4) has been isolated and sequenced from the inbred mouse strain MSKR derived from a Japanese wild mouse using polymerase chain reaction (PCR) methodology. The cDNA sequence of IL-4 of MSKR was found to contain several nucleotide alterations, which result in amino acid substitutions, in comparison with that of inbred m...