A facile and highly regioselective Pd-catalyzed oxidative coupling of N-tosylhydrazones providing efficient access to 2,3-disubstituted-1,3-butadienes has been developed. This process features readily available starting materials and mild reaction conditions. Further transformations of the obtained dibranched 1,3-dienes, through Diels-Alder reactions and indene synthesis, are also demonstrated,...

ABSTRACT Experimental and theoretical infrared spectra, between 4000 500 cm−1 (2.5–20 μm), band strengths of two solid phases indene, amorphous, crystalline, are given for the first time. The samples were generated via vapour deposition under high vacuum conditions on a cold surface. Density functional theory was employed calculations (IR) spectra. For lack previous information, monoclinic symm...

In the title compound, C16H16O4, the five-membered ring of the indene-1,3-dione unit adopts a twist conformation, whereas the seven-membered ring adopts a twist-chair conformation. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, weak C-H⋯O hydrogen bonds and π-π stacking [centroid-to-centroid distance = 3.7373 (8) Å] into a three-dimensional supra-molecular architecture.

We demonstrate a general approach for metabolic engineering of biocatalytic systems comprising the uses of a chemostat for strain improvement and radioisotopic tracers for the quantification of pathway fluxes. Flux determination allows the identification of target pathways for modification as validated by subsequent overexpression of the corresponding gene. We demonstrate this method in the ind...

An efficient and direct procedure for the synthesis of benzo[h]-indeno[1,2-b]-quinoline derivatives has been described. The procedure employs a three-component condensation reaction in one-pot using 2H-indene-1, 3-dione, naphthalen-1-amine,and aldehydes in the presence of catalytic amount of L-prolinein aqueous media.