Though new antiepileptic drugs are emerging, approximately a third of epileptic patients still suffer from recurrent convulsions and cognitive dysfunction. Therefore, we tested whether berberine (Ber), a vegetable drug, has an anticonvulsant property and attenuates memory impairment in a pilocarpine (Pilo)-induced epilepsy model in rats. The rats were injected with 400 mg/kg Pilo to induce conv...

Inter Carrier Efficient Method for falling ICI in OFDM Systems Interference (ICI) attributable to the Carrier Frequency Offset (CFO) and Doppler shifts; highly disgrace the performance of OFDM system. For OFDM communication system which is a capable technique for high data rate transmission, the theoretical BER and CIR are complicated to obtain in presence of ICI. The BER of the expected signal...

Arsenic (As) induces DNA-damaging reactive oxygen species. Most oxidative DNA damage is countered by base excision repair (BER), the capacity for which may be reduced in older animals. We examined whether age and consumption of As in lactational milk or drinking water influences BER gene transcript levels in mice. Lactating mothers and 24-week-old mice were exposed (24 h or 2 weeks) to As (2 or...

Berberine (Ber) and its main metabolites were identified and quantified using liquid chromatography/electrospray ionization/ion trap mass spectrometry. Rat plasma contained the main metabolites, berberrubine, thalifendine, demethyleneberberine, and jatrorrhizine, as free and glucuronide conjugates after p.o. Ber administration. Moreover, the original drug, the four main metabolites, and their g...

Base excision repair (BER) and mismatch repair (MMR) pathways play an important role in modulating cis-Diamminedichloroplatinum (II) (cisplatin) cytotoxicity. In this article, we identified a novel mechanistic role of both BER and MMR pathways in mediating cellular responses to cisplatin treatment. Cells defective in BER or MMR display a cisplatin-resistant phenotype. Targeting both BER and MMR...

The aim of this study was to investigate the performance enhancement of dual relay cooperative wireless network by using Amplify and Forward (AF) relaying protocol in Rician fading channel with different Kfactors. The bit error rate (BER) and BER gain by using AF scenario in Rician fading channel are derived. The results obtained from the proposed models are compared to AF scenario in Rayleigh ...

Cardiomyocyte apoptosis is an important event in doxorubicin (DOX)-induced cardiac injury. The aim of the present study was to investigate the protection of berberine (Ber) against DOX- triggered cardiomyocyte apoptosis in neonatal rat cardiomyocytes and rats. In neonatal rat cardiomyocytes, Ber attenuated DOX-induced cellular injury and apoptosis in a dose-dependent manner. However, Ber has no...

From in vitro studies, flap endonuclease 1 (FEN1) has been proposed to play a role in the long patch (LP) base excision repair (BER) subpathway. Yet the role of FEN1 in BER in the context of the living vertebrate cell has not been thoroughly explored. In the present study, we cloned a DT40 chicken cell line with a deletion in the FEN1 gene and found that these FEN1-deficient cells exhibited hyp...

Performance of cross-layer protocols that recommend the relay of corrupted packets to higher layers can be improved significantly by accurately inferring/predicting the bit error rate (BER) in the packets. Here, inference refers to estimating the BER in an already received packet, while prediction specifically refers to anticipating the BER in a future packet. This paper presents a measurement ...

A Chunk by chunk-based allocation is an emerging subcarrier allocation in Single Carrier Frequency Division Multiple Access (SC-FDMA) due to its low complexity. In this paper, a combined userorder and chunk-order allocation for solving chunk allocation problem which minimizes the average BER of all users while improving the throughput in SC-FDMA uplink is proposed. The subcarrier grouping into ...