Indole moiety is well-known as a superlative framework in many natural products and synthetic pharmaceuticals. Herein, we report an efficient procedure to synthesize series of functionalized 2-methyl-1H-indole-3-carboxylate derivatives from commercially available anilines properly by different electron-withdrawing -donating groups through palladium-catalyzed intramolecular oxidative coupling. T...

In recent years, it has become an urgent task to design new types of indole-based platform molecules for Nazarov-type cyclizations and develop organocatalytic synthesizing indole derivatives. To fulfill this task, in work, by changing the alkynyl terminal substituent from t-Bu aryl group, reactivity 3-alkynyl-2-indolylmethanols is modulated serve as competent substrates Brønsted acid-catalyzed ...

Asymmetric oxidation of heterocyclic sulfides, including imidazole, benzimidazole, indole and pyrimidine derivatives, were studied using a tartrate/Ti((i)OPr)4 catalyst system.

Enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC) and enteroaggregative E. coli (EAEC) are intestinal pathogens that cause food and water-borne disease in humans. Using biochemical methods and NMR-based comparative metabolomics in conjunction with the nematode Caenorhabditis elegans, we developed a bioassay to identify secreted small molecules produced by these pathogen...

Thirteen new 6-(1-H-indole-2-yl)-4-oxo-2-[2-(substituted-benzylidene)-hydrazinyl]-4,5-dihydropy-rimidine-5-carbonitrile derivatives were synthesized. The title compounds, hydrazones, were synthesized by reaction of hydrazine group of 2-hydrazinyl-4-(1-H-indole-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile (2) with different substituted aromatic aldehydes using a mixture (2:8, v/v) of glacial...

Direct cyanation of indole derivatives has been achieved with nontoxic K(4)[Fe(CN)(6)] as cyanating agent through Pd-catalyzed C-H bond activation.

Isatins, derivatives of indole, represent important class of compounds belonging to nitrogen heterocycles. These compounds comprise synthetically vital substrates that are used as precursors for drug synthesis and raw materials for heterocycles etc. Research in this group of compounds has engrossed interest among scientific community in recent and past as Isatins are known to possess immense bi...

Corrosion inhibition of Cu10Ni alloy in 0.5 M HCl solution using acrylonitrile derivatives namely: (E)-2(1H-indole-3-carbonyl)-3-(2-oxo-2-phenylethylthio)-3-(phenylamino)acrylonitrile(a),(E)-2-(1H-indole-3carbonyl)-3-mercapto-3-(phenylamino)acrylonitrile(b)and(Z)-2-(1H-indole-3-carbonyl)-3 phenylacrylonitrile (c) was investigated by potentiodynamic polarization, electrochemical impedance spectr...

THE reaction whereby l-tryptophan is broken down to indole by E. coli has been studied independently by Woods [1935, 1, 2] and by Happold & Hoyle [1935]. Woods worked with washed viable cells of the organism, whereas the latter investigators used suspensions killed in various ways but which, nevertheless, retained the property of catalysing this reaction. By coincidence both investigations, alt...