Repeated kindled seizures induce long-lasting physiological and morphological alterations in the hippocampal formation. In the dentate gyrus (DG), the morphological alterations induced by kindled seizures include loss of polymorphic neurons in the hilus, mossy fiber axon sprouting, and synaptic reorganization of the mossy fiber pathway. In this study, quantitative stereological methods were use...

PURPOSE To study the development of epilepsy following hypoxia-induced neonatal seizures in Long-Evans rats and to establish the presence of spontaneous seizures in this model of early life seizures. METHODS Long-Evans rat pups were subjected to hypoxia-induced neonatal seizures at postnatal day 10 (P10). Epidural cortical electroencephalography (EEG) and hippocampal depth electrodes were use...

objective: nitric oxide (no) plays an important role both as a consequence and as a cause of epileptic seizures.regarding the central nervous system depressant effects of achillea wilhelmsii (a. wilhelmsii), as well the effects of the plant on no, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of a. wilhelmsii on pentylenetetrazole (...

Introduction: Epilepsy is a group of chronic neurological disorders characterized by seizures. The aim of the present study was to investigate the effects of pretreatment with Satureja bachtiarica essential oil in preventing epilepsy. Methods: In this experimental study, 50 mice were randomly assigned to five groups of 10 each. The control group received normal saline plus tween80 and, 30 min ...

Experimental absence seizures are associated with perturbations in the presynaptic release of GABA and glutamate within thalamocortical circuitry. The release of both glutamate and GABA is regulated by group III metabotropic glutamate receptors (mGluRs). Therefore, we examined the susceptibility of mice lacking the mGluR4 subtype of mGluR (mGluR4(-/-)) versus their wild-type controls (mGluR4(+/...

Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose sei...

BACKGROUND Early childhood convulsions have been correlated with the finding of subsequent hippocampal neuronal loss and memory impairment in patients with intractable temporal lobe epilepsy. There is little direct evidence, however, that links early seizures with the later development of epilepsy and selective hippocampal neuronal loss. OBJECTIVE To study the long-term effect of early seizur...

Introduction: Pulicaria gnaphalodes contains terpenoids and flavonoids. Referring to the role of benzodiazepine (BZD) receptor ligands as drug candidates in the treatment of epilepsy, anxiety and sleep disturbances, and since natural flavonoids are among these candidates and hold promise as BZD receptor ligands, this research was done to assess the effects of aqueous extract and essential oi...

Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...