Philadelphia chromosome positive de novoacute myeloid leukemia (AML)is a rare disease with reported incidence of less than 1% of newly diagnosed cases of AML. Outcome of the disease is poor, owing to its resistance to conventional chemotherapy and variable response to imatinib besylate. We report a case of 24-year man who reported to our unit in November 2014 and was treated with conventional i...

Spontaneous rupture of the spleen (SRS) is a rare clinical entity with potentially poor medical outcome. In most cases, SRS caused by neoplastic disorder. Acute promyelocytic leukaemia but important cause that physicians are required to assess for. We present 28-year-old woman APL and COVID-19 pneumonia, who successfully underwent embolisation splenic artery for spontaneously occurring during i...

INTRODUCTION The long-term prognosis of induction chemotherapy followed by surgery for N2 non-small lung cell cancer (NSCLC) remains controversial. PATIENTS AND METHODS We retrospectively reviewed the data and assessed the prognosis of 31 N2-NSCLC patients who underwent induction chemotherapy followed by surgery at our institution between January 1999 and December 2013. Potential prognostic f...

conclusions this study demonstrates that using either honey or normal saline can reduce the rate and severity of chemotherapy induced mucositis. background oral mucositis is a frequent problem after high-dose chemotherapy which could impair patient’s quality of life, higher rates of infections, and delay in subsequent chemotherapy. objectives the present study was performed to assess the effect...

The current approach to breast cancer has problems with the emergence of resistance, side effects, and even post-therapy relapses. One reasons is that available chemotherapy still based on cytotoxicity through cell cycle inhibition apoptosis induction. In fact, there are several mechanisms for direction become more prospective targets action, such as reactive oxygen species (ROS) leading death ...

The development of cisplatin-based induction chemotherapy followed by surgical resection or radiation has improved the poor prognosis of stage III non-small cell lung cancer (NSCLC). In vitro studies indicate that p53 can modulate cisplatin-induced cytotoxicity, but the molecular genetic features determining response or resistance to cisplatin in vivo must be defined. For this reason, tumor spe...

High-risk acute myelogenous leukemia (AML) constitutes a distinct subset of disease based on clinical and biological characteristics and comprises a significant percentage of all cases of adult AML. Biologic features such as distinct clonal cytogenetic and molecular abnormalities identify a subgroup of AML patients characterized by poor response to induction chemotherapy and poor long-term surv...

Patients with resectable stage IIIA-N2 non-small cell lung cancer should receive induction chemotherapy before surgery. The aim is to early control systemic disease, eventually cure the mediastinal tumor spread and improve patients' survival. A recent metanalysis of randomized trials with second-generation platinum-based combinations has reinforced the evidence concerning the benefit of inducti...

The limited sensitivity of the historical treatment response criteria for acute myeloid leukemia (AML) has resulted in a different paradigm for treatment compared with most other cancers presenting with widely disseminated disease. Initial cytotoxic induction chemotherapy is often able to reduce tumor burden to a level sufficient to meet the current criteria for "complete" remission. Neverthele...