Progress in genomics and the associated technological, statistical and bioinformatics advances have facilitated the successful implementation of genome-wide association studies (GWAS) towards understanding the genetic basis of common diseases. Infectious diseases contribute significantly to the global burden of disease and there is robust epidemiological evidence that host genetic factors are i...

BACKGROUND We estimated U.S. biomedical research funding across therapeutic areas, determined the association with disease burden, and evaluated new drug approvals that resulted from this investment. METHODOLOGY/PRINCIPAL FINDINGS We calculated funding from 1995 to 2005 and totaled Food and Drug Administration approvals in eight therapeutic areas (cardiovascular, endocrine, gastrointestinal, ...

INTRODUCING THE NEGLECTED TROPICAL DISEASES Over the past two centuries, advances in the understanding of communicable diseases have led to considerable reductions in their global burden. Due to advances in sanitation, germ theory, vaccination, antimicrobial drugs, and other factors, infectious disease is no longer the leading cause of death in the developed world.1 In poor areas of the world, ...

Climate change is likely to profoundly modulate the burden of infectious diseases. However, attributing health impacts to a changing climate requires being able to associate changes in infectious disease incidence with the potentially complex influences of climate. This aim is further complicated by nonlinear feedbacks inherent in the dynamics of many infections, driven by the processes of immu...