Spermatogenesis is a highly controlled process of proliferation, meiosis, and differentiation. Systemic infection and chronic inflammation can impair testicular steroidogenesis and spermatogenesis. In this study, we examined the effect of systemic infection--intraperitoneal (i.p.) injection of lipopolysaccharide (LPS)--on the expression levels of IL-6 in the testis of sexually immature and adul...

The challenging response of Physis to inflammation is a 7-part series, which covers all aspects of inflammation, from how and why it occurs to healthcare advice on healthy lifestyle choices. Part 1: Overview and historical significance of inflammation Part 2: Nature and role of inflammation – benefits and drawbacks Part 3: Stress, lifestyle factors and inflammation Part 4: Tibb and conventional...

the leukotrienes and prostaglandins are biologically active metabolites derived from arachidonic acid. the leukotrienes have a role in inflammatory diseases such as allergic rhinitis, inflammatory bowel disease and asthma. montelukast, a cysteinyl leukotriene receptor antagonist, is claimed to be effective in asthma. the present study aimed to assess the role of cysteinyl leukotriene receptor a...

During acute inflammation, functioning lymphatics are believed to reduce edema and to provide a transiting route for immune cells, but the extent at which the dermal lymphatic remodeling impacts lymphatic transport or the factors regulating these changes remains unclear. Herein we quantify the increase in lymphatic endothelial cells (LECs) and examine the expression of pro-angiogenenic and lymp...

cells for Mel-ILP responsiveness, in a subset of melanoma patients (2). However, in our opinion, it is tough to conclude from the results Martner and colleagues present that melphalan alone can induce immunogenic cell death (ICD), and additional analyses are required to validate this clinically (1, 3). For instance, T-cell effector responses intratumorally are known to differ from those in peri...

Over the past decades evidence has accumulated clearly demonstrating a pivotal role for the sympathetic nervous system (SNS) and its neurotransmitters in regulating inflammation. The first part of this review provides the reader with an overview showing that the interaction of the SNS with the immune system to control inflammation is strongly context-dependent (for example, depending on the act...

tuberculosis is a major health problem in iran and its laryngeal involvement is not uncommon. laryngeal tuberculosis is so infectious and delay in diagnosis and treatment could result spread of disease and causes divesting complications. we reviewed clinical and para-clinical characteristics of patients with laryngeal tuberculosis in iran. in a cross sectional study, patients with laryngeal tub...

objective(s): inflammation is an immune response toward injuries. although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, alzheimer’s and various cancer. indonesian cassia (cinnamomum burmanni c. nees & t. ness) known to contain coumarin, is widely used for alternative medicine es...

one of the most common outcomes of pulp inflammation is periapical granuloma formation. existence of immune cells in these lesions showed involvement of both humoral and cellular immunity in the site. the presence of different antigens in the root canal causes production o various antibodies and consequent immunological reactions. different theories have been proposed on periapical cysts. the m...

Macrophages accumulate in poorly vascularised and hypoxic sites including solid tumours, wounds and sites of infection and inflammation where they can be exposed to low levels of oxygen for long periods. Up to date, different studies have shown that a number of transcription factors are activated by hypoxia which in turn activate a broad array of mitogenic, pro-invasive, pro-angiogenic, and pro...