Inflammations form an integral part of the innate immunity against pathogenic infections. NF-κB represents a family of inducible transcription factors, which regulates a large array of genes involved in different processes of the immune and inflammatory responses. It is now clear that NF-κB signaling pathway is involved in the regulation of inflammation, contributing to the initiati...

Persistent macrophage activation is associated with the expression of various pro-inflammatory genes, cytokines and chemokines, which may initiate or amplify inflammatory disorders. A novel synthetic BET inhibitor, JQ1, was proven to exert immunosuppressive activities in macrophages. However, a genome-wide search for JQ1 molecular targets has not been undertaken. The present study aimed at eval...

Neurological inflammatory diseases are developing rapidly. Different factors involved in the pathogenesis of these diseases. In this article, we discuss some of the mechanisms are dealt with. An aberrant procedure of beta-amyloid precursor protein (BAPP) to form neurotoxic beta-amyloid peptides and an accumulated insoluble polymer of beta –amyloid (BA) that forms the senile plaque. The ab...

Abstract Monocyte-derived macrophages (mo-macs) acquire a spectrum of pro- and anti-inflammatory functions during infection-associated inflammation resolution. Quantification mo-mac functional state is critical to elucidate mechanisms leading dysregulation inflammatory control how these processes can be manipulated therapeutically. Given that binary M1/M2 cell markers often fail explain macroph...

Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Here, we studied transcriptional regulation in homocysteine (Hcy)-induced gene expression in monocytes (MC). We identified 11 Hcy-induced genes, 17 anti-inflammatory cytokine interleukin 10-induced, 8 pro-inflammatory cytokine interferon gamma (IFN gamma)-induced and 8 pro-inflammatory cytokine tumor necrosis ...

Quality-based assessment of pharmaceuticals obviates the uncertainties concerning their quality, safety and efficacy for regulatory purpose. A method was developed validated quality control cefadroxil or row material analysis. In-silico analysis wasperformedto evaluate bioavailability, toxicity as well asanti-inflammatory potential cefadroxil. The results showed that found linear, accurate, pre...

Post-traumatic stress disorder (PTSD) confers an increased risk for disorders with an inflammatory etiology. PTSD-related dysregulation of the sympathetic nervous system (SNS) and hypothalamic-pituitary adrenal (HPA) axis and associated alterations in inflammatory activity may contribute to this increased risk. However, little is known about convergent SNS, HPA and inflammatory signaling at the...

Long noncoding RNAs (lncRNAs) can harbor DNA binding domains and regulate target gene expressions by to their promoter regions. Although a large proportion of differentially expressed lncRNAs have been identified in psoriatic skin, chronic inflammatory disease enriched pro-inflammatory genes, cell type specificity are yet be revealed. We performed scRNA-seq experiments non-lesional skin lesiona...

HS is inflammatory skin disease with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas. The lack of an animal model, which could faithfully recapitulate most features, a major impediment defining pathobiology and developing effective treatment. In this study, we developed experimental models to elucidate underlying mechanisms pathobiology, screen potent drug molecules. ...

Curcumin is active component of turmeric and isolated from the rhizome of turmeric, a phenolic natural product. One of inflammatory disease is multiple sclerosis, a multifocal chronic autoimmune inflammatory disease of the CNS, which is also known as a perivascular demyelinating disease. Studies have been shown that neuro-inflammation can have both harmful and beneficial effects on the neuronal...