Background Idiopathic inflammatory myopathies (IIM) are a group of rare, heterogeneous diseases in which the hallmark feature is chronic inflammation skeletal muscle leading to weakness. Initial conventional therapy based on expert opinion and includes glucocorticoids combination with methotrexate, azathioprine, or mycophenolate. If this not sufficiently effective, second line (calcineurin inhi...

antidepressants are widely used for the treatment of various neuropathic pain conditions in humans. recent studies have demonstrated that bupropion is effective for the treatment of neuropathic pain. also antidepressants like bupropion showed anti-inflammatory properties. so in the present study, the analgesic and anti-inflammatory effects of bupropion in mice and rat were investigated. the ace...