Serum leptin levels reflect the amount of body fat. However, several reports suggest that insulin may also regulate serum leptin levels. This study was aimed at testing whether leptin levels are low in newly diagnosed patients with type 1 diabetes and increase after institution of insulin therapy. Nineteen children with new-onset type 1 diabetes were studied. Serum leptin levels were measured a...

Despite the essential role of insulin in the management of patients with insulin deficiency, insulin use can lead to adverse effects such as hypoglycaemia and weight gain. Rarely, crucial fluid retention can occur with insulin therapy, resulting in an oedematous condition. Peripheral or generalised oedema is an extremely rare complication of insulin therapy in the absence of heart, liver or ren...

Historical Background 461 Types of Insulin 461 Rapid-Acting Insulins 461 Intermediate-Acting Insulins 462 Long-Acting Insulins 462 Insulin Purity, Species, and Concentration 463 Beef and Pork Insulins 463 Human Insulin 463 Insulin Concentrations 464 Initiation of Insulin Therapy 464 Coals of Therapy 465 Treatment Strategies 466 Single-Dose Regimens 466 Twice-Daily Regimens 467 Multiple Daily In...

Type 1 diabetes mellitus patients on intensive insulin therapy use advanced carbohydrate counting to proper dose prandial insulin. Therefore, the patient’s ability accurately estimate meal’s content is paramount. However, despite its significance, several studies show that estimates far from ideal and identify need for continuous education counting. In this context, authors have proposed in pre...

background and objectives: diabetes mellitus and periodontal disease are two chronic and common diseases with close relationship together affecting public health and quality of life. the aim of this study was to investigate the effect of resveratrol supplementation in adjunct with non-surgical periodontal treatment (nst) on blood glucose, triglyceride, periodontal status and inflammatory marker...

insulin is currently the drug of choice in treating patients with gestational diabetes mellitus but insulin is expensive, inconvenient to store and use and probably associated with more risks of asymptomatic hypoglycemia in comparison with some oral agents. this randomized clinical trial was conducted to evaluate the efficacy and safety of glyburide in patients with gestational diabetes mellitu...

OBJECTIVE To assess adherence and persistence to insulin therapy and identify its associated factors among Chinese insulin-naïve patients with type 2 diabetes (T2D). METHODS Tianjin Urban Employee Basic Medical Insurance claims database was used (2008-2011). Adult patients with T2D who initiated insulin therapy during January 2009 through December 2010 and were continuously enrolled for 12 mo...

RATIONALE Hyperglycemia and insulin resistance have been shown to increase morbidity and mortality in severely burned patients, and glycemic control appears essential to improve clinical outcomes. However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality. OBJECTIVES To determine wheth...

introduction: low-level laser therapy (lllt) is shown effective in healing diabetic foot ulcer when combined with conventional therapy. since; diabetes mellitus is a leading cause of impaired wound healing. the aim of this study is to determine the effect of different diabetic control’s methods on the healing response of diabetic foot ulcer in those patients treated with low level laser therapy...

Diabetes mellitus (DM) is a public health issue, affecting around 382 million people worldwide. In order to achieve glycemic goals, insulin therapy is the frontline therapy for type 1 DM patients; for patients with type 2 DM, use of insulin therapy is an option as initial or add-on therapy for those not achieving glycemic control. Despite insulin therapy developments seen in the last decades, s...