Low-intensity pulsed ultrasound (LIPUS) is commonly used for bone fracture healing to mechanically stimulate a site and accelerate the repair process. Recent studies reported that LIPUS stimulation could have various effectiveness such as not only but also regenerative medicine of articular cartilage cognitive dysfunction improvement. However, conventional devices both affected unaffected sites...

Poly-L-lactic acid (PLLA) nanofibrous membranes are widely utilized for tissue regeneration. Low intensity pulsed ultrasound (LIPUS) has been considered as a feasible modality for bone union. The aim of the present study was to investigate the potential synergistic effect of LIPUS and PLLA electrospun nanofibrous membranes on large cortical bone defects in rabbits in vivo. The bilateral rabbit ...

BACKGROUND Although a significant progress has been made in the management of ischemic heart disease (IHD), the number of severe IHD patients is increasing. Thus, it is crucial to develop new, non-invasive therapeutic strategies. In the present study, we aimed to develop low-intensity pulsed ultrasound (LIPUS) therapy for the treatment of IHD. METHODS AND RESULTS We first confirmed that in cu...

Adult stem cells can differentiate into multiple lineages depending on their exposure to differing biochemical and biomechanical inductive factors. Lack of mechanical signals due to disuse can inhibit osteogenesis and induce adipogenesis of mesenchymal stem cells (MSCs). Long-term bed rest due to both brain/spinal cord injury and space travel can lead to disuse osteoporosis that is in part caus...

OBJECTIVE Patellar tendinopathy (PT) is a common and significant clinical condition for which there are few established interventions. One intervention that is currently being used clinically to manage PT symptoms is the introduction of low-intensity pulsed ultrasound (LIPUS). The aim of this study was to investigate the clinical efficacy of LIPUS in the management of PT symptoms. METHODS A r...

It is estimated that approximately 5% to 10% of fractures will evolve into nonunions. Nonunions have a significant impact on patient quality life and socioeconomic costs. Low-intensity pulsed ultrasound (LIPUS) non-invasive therapy widely used within the orthopedic community accelerate healing fresh fractures, minimize delayed healing, promote In this case series, 46 nonunions 19 were treated w...