The innate immune system responds within minutes of infection to produce type I interferons and pro-inflammatory cytokines. Interferons induce the synthesis of cell proteins with antiviral activity, and also shape the adaptive immune response by priming T cells. Despite the discovery of interferons over 50 years ago, only recently have we begun to understand how cells sense the presence of a vi...

conclusions snps within the ccr5 gene should be considered as an important factor used in combination with other host gene snps when developing a mathematical model for anticipating response to hcv therapy. background chronic hepatitis c virus (hcv) infection is a globally serious public health issue. objectives in this study, we investigated cc chemokine receptor 5 (ccr5-59029) polymorphism wh...

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

background molecular farming is the production of important recombinant proteins in transgenic organisms on an agricultural scale. interferons are proteins with antiviral and antitumor activities and can be used for viral infections and cancers treatments. objectives this study reports the transformation of inf α2b gene in tobacco plant for the first time in iran. materials and methods interfer...

A convenient assay for interferons based on reduction of cytopathic effect was developed. The number of manipulations and the lengths of the various incubation steps were reduced to a minimum. The assay is simple to perform and can be completed within 16 h. Moreover, it can be used with various types of cells and a variety of viruses.

Interferon is a popular topic today and a textbook on the subject attracts the eye of the casual and generally uninformed reader. As with all popular entities, especially those with putative curative powers, interferon (or, correctly, the interferons) is surrounded by much myth. In this volume Dr. Yabrow has done little to separate fact from fancy. Interferon and Non-Specific Resistance attempt...

Interferon is a popular topic today and a textbook on the subject attracts the eye of the casual and generally uninformed reader. As with all popular entities, especially those with putative curative powers, interferon (or, correctly, the interferons) is surrounded by much myth. In this volume Dr. Yabrow has done little to separate fact from fancy. Interferon and Non-Specific Resistance attempt...

I NTERFERONS are a family of inducible secretory glycoproteins produced by eukaryotic cells in response to viral infections or other stimuli. They are intercellular messages which, upon binding to specific cell surface receptors, direct cells to express a new, interferon-induced, phenotype. They have, therefore, aptly been called “inducible inducers.” Characteristically, all interferons induce ...

Interferon is produced in cultures of rabbit leukocytes in response to infection with Newcastle disease virus or in the absence of known viral infection. The macrophage appears to be the responsible producing cell. Cultures prepared from sterile peritoneal exudates, which contained about 90% macrophages, are at least as efficient as cultures of rabbit kidney (RK) cells in their capacity to synt...