BACKGROUND The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow waves. The absence of intramuscular interstitial cells in W/WV mutants provides a unique opportunity to study the molecular changes that are associated with the loss of the...

Chronic intestinal pseudo-obstruction (CIPO) is a rare gastrointestinal motility disorder that presents with symptoms, physical exam, and imaging findings of mechanical bowel obstruction without an anatomical obstruction. Multiple etiologies, including enteric or extrinsic neuropathic dysfunction, myopathic dysfunction the interstitial cells Cajal, cause CIPO’s pathogenesis. The presentation CI...

Pancreatic adenocarcinoma is the most pervasive form of cancer with high mortality rates. Being obscure at early stages, non-specific symptoms and their onset only in late stages disease lead to detection III–IV on initial diagnistics. Gastrointestinal stromal tumor (GIST) an intramucosal gastrointestinal tract, which a derivate interstitial cells Cajal. The unicity presented clinical case rare...