An in vitro experiment was conducted to determine the effect of supplemental non-fiber carbohydrate(NFC) on the disappearance kinetics of cellulose (Ce) by mixed ruminal microorganisms. Non-supplementedor NFC supplemented cellulose (467 mg NFC/g cellulose as sucrose (CeSu) or starch (CeSt) or a 1:1 mixtureof sucrose + starch (CeSuSt)) were incubated for 24, 48, and 96 h at 39°C. After each incu...

Seven cannulated (rumen and duodenal) Angus x Hereford steers (264 +/- 8 kg BW) consuming low-quality forage (5% CP; 61% NDF; 31% ADF) were used to determine the influence of CP degradability and supplementation frequency (SF) on DMI and nutrient digestion. Treatments included an unsupplemented control and degradable intake protein (DIP) or undegradable intake protein (UIP) provided daily, ever...

The intestinal absorption of a prodrug is affected by a number of factors, such as its membrane permeability, stability in the gut lumen, and conversion to the parent drug in enterocytes. We evaluated the absorption of ME3229, an ester-type prodrug of a hydrophilic glycoprotein IIb/IIIa antagonist. Although the octanol/water distribution coefficient and permeability across a Caco-2 cell monolay...

The chemical composition, degradability coefficients (in situ) and ruminal-intestinal disappearance(mobile bag procedure) of dry matter (DM) and crude protein (CP) were evaluated for olive cake (OC)silages treated (DM basis) with additives as follows: (1) untreated OC, (2) OC + 0.5% urea, (3) OC + 0.4%formic acid, (4) OC + 8% molasses, (5) OC + 0.5% urea + 8% molasses, (6) OC + 0.5% urea + 0.4%...

Although epidemiological studies strongly suggest an association between gastric cancer and Helkobacter pylon infection, there has been no clinical report indicating that cure of the infection prevents cancer. We conducted a nonrandomized H. pylon eradication trial in patients whose gastric cancer was removed by endoscopic resection (ER). We investigated the effect of treatment on the histopath...

Although epidemiological studies strongly suggest an association between gastric cancer and Helicobacter pylori infection, there has been no clinical report indicating that cure of the infection prevents cancer. We conducted a nonrandomized H. pylori eradication trial in patients whose gastric cancer was removed by endoscopic resection (ER). We investigated the effect of treatment on the histop...

Intestinal epithelial cell damage is frequently seen in the mucosal lesions of infectious or inflammatory bowel diseases such as ulcerative colitis or Crohn's disease. Complete remission of these diseases requires both the disappearance of inflammation and the repair of damaged epithelium. Saccharomyces boulardii (Sb, Biocodex) is a non-pathogenic yeast widely used as a preventive and therapeut...