Introduction: The nasal cavity is a promising site for drug delivery as it is easily accessible to patients, has a large surface area (due to the presence of microvilli), contains a thin nasal epithelium, and it can bypass first-pass metabolism [1]. However, many conventional dosage forms (e.g. gels, solutions, suspensions) have low residence time (time at site of action) within the nasal cavit...

BACKGROUND Delivery of powder formulations to the nose is an attractive alternative for many drugs and vaccines. This study compared the regional nasal deposition and clearance patterns of lactose powder delivered by the OptiNose powder device (Opt-Powder; OptiNose US Inc., Yardley, PA, USA) to that of liquid aerosol administered via a traditional hand-actuated liquid spray pump (Rexam SP270, R...

Stem cell-based therapies for neurological disorders, including brain tumors, advance continuously toward clinical trials. Optimized cell delivery to the central nervous system remains a challenge since direct intracerebral injection is an invasive method with low transplantation efficiency. We investigated the feasibility of intranasal administration of neural stem/progenitor cells (NSPCs) as ...

The nasal mucosa provides a potentially good route for local and systemic drug delivery. However, the protective feature of the nasal cavity make intranasal delivery challenging. The application of mucoadhesive polymers in nasal drug delivery systems enhances the retention of the dosage form in the nasal cavity. Several groups have investigated using low acyl gellan as a drug delivery vehicle b...

conclusions there is no statistically significant relationship between preterm delivery and type of sludge. results the prevalence of preterm delivery was 14/3%. the frequencies of term delivery in mothers with dense, light and no sludge were 78/6%, 82/1% and 96/4 % respectively, and for preterm delivery they were 21/4%, 17/9% and 3/6% respectively. but there was no statistically significant re...

OBJECTIVE To explore interrater and intrarater reliability (R (inter) and R (intra), respectively) of a standardized scale applied to nasoendoscopic assessment of velopharyngeal (VP) function, across multiple centers. DESIGN Multicenter blinded R (inter) and R (intra) study. SETTING Eight academic tertiary care centers. PARTICIPANTS Sixteen otolaryngologists from 8 centers. MAIN OUTCOME...

The long-standing observations that respiratory secretions contain virus-neutralizing substances (1-3) have recently been extended by the demonstration that antibody activity associated with the yA-globulin in nasal secretion may protect against respiratory virus infection (4). Since protection was most clearly seen in individuals with relatively high titers of nasal antibody, and since yA-glob...