OBJECTIVE To determine if supplemental intraarticular α2-macroglobulin (α2 M) has a chondroprotective effect in a rat model of osteoarthritis (OA). METHODS Using Western blotting, mass spectrometry, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry, α2 M was identified as a potential therapeutic agent through a comparison of α2 M concentrations in serum, synovial fluid (SF),...

BACKGROUND/AIM Both bupivacaine and levobupivacaine are local anesthetics with strong analgesic efficacy that can be used intraarticularly. The aim of this study was to compare the effects of intraarticular bupivacaine and levobupivacaine injection on inflammation in articular cartilage and the synovium of the rat knee joint. MATERIALS AND METHODS Twenty Sprague-Dawley rats were injected in t...

Background: The present study evaluates the safety and efficacy of intraarticular injections leucocyte poor platelet rich plasma (LP-PRP) in osteoarthritis (OA) knee patients. Patients with early (K-L grading 1 2)-clinically radiologically those who gave consent to participate were injected 2.4 ml per LP-PRP over unilateral or bilateral knees at 0, 1, 2 6 months injections. Methods: 100 patient...

Objective: The objective of this study was to evaluate whether ultrasound-guided intraarticular (IA) glenohumeral injection applied before physical therapy and exercise program (PTETP) contributes the treatment outcomes in patients with adhesive capsulitis shoulder (ACS). Methods: medical records 93 diagnosed ACS who underwent same modalities five sessions per week for three weeks (consisted su...

Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attemp...

Objective: The objective of this study was to evaluate the effect different molecular weight (MW) hyaluronic acid (HA) application on pain and functional parameters in knee osteoarthritis (OA).
 Methods: This designed as retrospectively. Hospital records patients who received intraarticular HA injection therapy our center were screened. divided into 3 categories according MW preparates fol...